Vincent Idone

Regeneron (United States) — United States

Medicine · Health Sciences

17h-index2.2kcitations33works3.42yr avg
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Research Topics

Heterotopic Ossification and Related Conditions(14), Parathyroid Disorders and Treatments(11), Medical Imaging and Pathology Studies(11), TGF-β signaling in diseases(5), Cellular transport and secretion(4)

Publications33 total

CryoEM structure of ALK2:BMP6 reveals distinct mechanism that allow ALK2 to interact with both BMP and activin ligands
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humans
JCI Insight·2025· 1 citedOpen Access
CryoEM structure of ALK2:BMP6 reveals distinct mechanisms that allow ALK2 to interact with both BMP and Activin ligands
2025Open Access
Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch
2024· 2 citedOpen Access
How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva
Biomolecules·2024· 13 citedOpen Access
Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis
Nature Genetics·2023· 23 citedOpen Access
S281: TMPRSS6 INHIBITION WITH A MONOCLONAL ANTIBODY IMPROVES RED BLOOD CELL HEALTH AND IRON OVERLOAD IN A MOUSE MODEL OF BETA-THALASSEMIA
HemaSphere·2023Open Access
Activin E–ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice
Proceedings of the National Academy of Sciences·2023· 33 citedOpen Access
TMPRSS6 Inhibition with a Monoclonal Antibody Improves Red Blood Cell Health and Reduces Hepatic Iron Loading in Mouse Models of Iron Overload Diseases
Blood·2022· 2 cited
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes
Nature Communications·2022· 49 citedOpen Access
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
Journal of Clinical Investigation·2022· 60 citedOpen Access
Sex-specific reduction in inflammation of osteoarthritic human chondrocytes and nutraceutical-dependent extracellular matrix formation
Journal of Immunology and Regenerative Medicine·2021· 2 citedOpen Access
Combining stretching and gallic acid to decrease inflammation indices and promote extracellular matrix production in osteoarthritic human articular chondrocytes
Experimental Cell Research·2021· 13 citedOpen Access
ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
2021· 1 citedOpen Access
<i>In vitro</i> effects of nutraceutical treatment on human osteoarthritic chondrocytes of females of different age and weight groups
Journal of Nutritional Science·2021Open Access
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
eLife·2020· 78 citedOpen Access
Author response: Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
2020Open Access
The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors
2019· 1 citedOpen Access
An Acvr1[R258G] conditional on' mouse model of atypical fibrodysplasia ossificans progressiva (FOP) is Activin A dependent
Bone Abstracts·2019· 1 cited
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
PubMed·2019· 37 cited
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Frequent Co-authors

Aris N. Economides(23), Sarah Hatsell(14), Kalyan C. Nannuru(11), Andrew Murphy(11), Senem Aykul(11), Erich J. Goebel(9), Lily Huang(7), Lili Wang(7), John B. Lees‐Shepard(7), Nanditha Das(6), Richard A. Corpina(6), Xialing Wen(5), Johanna Jimenez(5), Norma W. Andrews(5), Nyanza J. Rothman(5), Thomas B. Thompson(5), Hyon J. Kim(4), Liqin Xie(4), Paul B. Yu(4), Christina Tam(4)