Erich J. Goebel

Regeneron (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index496citations26works2.72yr avg
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Research Topics

TGF-β signaling in diseases(13), Heterotopic Ossification and Related Conditions(8), Parathyroid Disorders and Treatments(6), Medical Imaging and Pathology Studies(5), Bone Metabolism and Diseases(4)

Publications26 total

The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin
2025
CryoEM structure of ALK2:BMP6 reveals distinct mechanism that allow ALK2 to interact with both BMP and activin ligands
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Molecular mechanism of Activin receptor inhibition by DLK1
Nature Communications·2025Open Access
CryoEM structure of ALK2:BMP6 reveals distinct mechanisms that allow ALK2 to interact with both BMP and Activin ligands
2025Open Access
Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch
2024· 2 citedOpen Access
How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva
Biomolecules·2024· 13 citedOpen Access
The orphan ligand, activin C, signals through activin receptor-like kinase 7
eLife·2022· 35 citedOpen Access
Author response: The orphan ligand, activin C, signals through activin receptor-like kinase 7
2022Open Access
The orphan ligand, Activin C, signals through activin receptor-like kinase 7
2022· 1 citedOpen Access
Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors
iScience·2021· 16 citedOpen Access
Characterization of tolloid-mediated cleavage of the GDF8 procomplex
Biochemical Journal·2021· 9 citedOpen Access
Heparin-mediated dimerization of follistatin
Experimental Biology and Medicine·2020· 7 citedOpen Access
Structural perspective of BMP ligands and signaling
Bone·2020· 61 citedOpen Access
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
eLife·2020· 78 citedOpen Access
Author response: Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
2020Open Access
Structural biology of the TGFβ family
Experimental Biology and Medicine·2019· 40 citedOpen Access
The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors
2019· 1 citedOpen Access
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
PubMed·2019· 37 cited
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity
Proceedings of the National Academy of Sciences·2019· 62 citedOpen Access
Structural Insight into the Activin Receptor Assembly Mechanism
The FASEB Journal·2019
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Frequent Co-authors

Thomas B. Thompson(17), Aris N. Economides(9), Vincent Idone(9), Senem Aykul(8), Roselyne Castonguay(6), Ravindra Kumar(6), Richard A. Corpina(5), John B. Lees‐Shepard(5), Magdalena Czepnik(4), Jason C. McCoy(4), Daniel J. Bernard(4), Erik Martı́nez-Hackert(4), Kaitlin N. Hart(4), Emily C Kappes(4), Chandramohan Kattamuri(4), Ryan G. Walker(3), Andrew P. Hinck(3), Camille J. Cunanan(3), Alexandra Dimitriou(3), Ashique Rafique(3)