John B. Lees‐Shepard

Regeneron (United States) — United States

Medicine · Health Sciences

8h-index557citations19works7.52yr avg
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Research Topics

Heterotopic Ossification and Related Conditions(14), Medical Imaging and Pathology Studies(11), Parathyroid Disorders and Treatments(9), Osteoarthritis Treatment and Mechanisms(2), Trypanosoma species research and implications(2)

Publications19 total

Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch
2024· 2 citedOpen Access
How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva
Biomolecules·2024· 13 citedOpen Access
Skeletal phenotype amelioration in mucopolysaccharidosis VI requires intervention at the earliest stages of postnatal development
JCI Insight·2023· 8 citedOpen Access
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
Journal of Clinical Investigation·2022· 60 citedOpen Access
Defining phenotype reversibility in lysosomal disease: Leveraging a COIN model in mucopolysaccharidosis type VI (MPS VI)
Molecular Genetics and Metabolism·2022
Cross‐talk between <scp>EGFR</scp> and <scp>BMP</scp> signals regulates chondrocyte maturation during endochondral ossification
Developmental Dynamics·2021· 10 cited
An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva mice
2021· 3 citedOpen Access
ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
2021· 1 citedOpen Access
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
eLife·2020· 78 citedOpen Access
Author response: Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
2020Open Access
The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors
2019· 1 citedOpen Access
Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
eLife·2019· 7 citedOpen Access
Decision letter: Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass
2018Open Access
Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity
eLife·2018· 73 citedOpen Access
Author response: Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity
2018· 1 citedOpen Access
Scientists Discover Cells Responsible For Stone Man Syndrome
Science Trends·2018Open Access
Stem cells and heterotopic ossification: Lessons from animal models
Bone·2018· 62 cited
Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva
Nature Communications·2018· 238 citedOpen Access
The Epidermal Growth Factor Receptor Regulates Chondrogenic Differentiation
OpenCommons - UConn (University of Connecticut)·2013

Frequent Co-authors

Aris N. Economides(9), David J. Goldhamer(7), Senem Aykul(7), Kalyan C. Nannuru(7), Nyanza J. Rothman(7), Vincent Idone(7), Erich J. Goebel(5), Andrew Murphy(5), Sean J. Stoessel(4), Parvathi M. Devarakonda(4), Nanditha Das(4), Sarah Hatsell(4), Masakazu Yamamoto(3), Sarah-Anne E. Nicholas(3), Michael J. Schneider(3), Richard A. Corpina(3), Camille J. Cunanan(3), Alexandra Dimitriou(3), Qian Zhang(3), Ashique Rafique(3)