Björn Windshügel

Constructor University — Germany

Computer Science · Physical Sciences

15h-index895citations54works2.62yr avg
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Research Topics

Computational Drug Discovery Methods(11), Pharmacogenetics and Drug Metabolism(11), Estrogen and related hormone effects(10), Receptor Mechanisms and Signaling(8), Hormonal Regulation and Hypertension(7)

Publications54 total

Structure‐based discovery of thiamine uptake inhibitors
British Journal of Pharmacology·2025· 1 citedOpen Access
Novel aryl hydrocarbon receptor agonists as potential anti-inflammatory therapeutics: Identification and validation through drug repurposing
Biochemical Pharmacology·2025· 4 citedOpen Access
Identification, validation, and characterization of approved and investigational drugs interfering with the <scp>SARS</scp>‐<scp>CoV</scp>‐2 endoribonuclease Nsp15
Protein Science·2025Open Access
Disassembly of the <i>Escherichia coli</i> AcrABZ-TolC efflux pump by ligand-mediated disruption of TolC-AcrA interfacial contacts
2025· 3 citedOpen Access
BPS2025 - Disrupting resistance: A novel inhibitor targeting antimicrobial efflux
Biophysical Journal·2025
BPS2025 - Disrupting resistance: A novel inhibitor targeting antimicrobial efflux
Biophysical Journal·2025
Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2
ACS Pharmacology & Translational Science·2024Open Access
Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with <i>Staphylococcus aureus</i> Virulence
ACS Infectious Diseases·2024· 3 citedOpen Access
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex
Virus Research·2024· 12 citedOpen Access
Resolving the pharmacological redox-sensitivity of SARS-CoV-2 PLpro in drug repurposing screening enabled identification of the competitive GRL-0617 binding site inhibitor CPI-169
2023· 2 citedOpen Access
Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators
Biomolecules·2023· 2 citedOpen Access
Drug Repurposing Screen to Identify Inhibitors of Sars-Cov-2 Minimal Functional Replication and Transcription Complex
SSRN Electronic Journal·2023Open Access
Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches
Cancers·2022· 4 citedOpen Access
Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR
Cells·2022· 4 citedOpen Access
Structure‐based discovery of small molecules improving stability of human broadly‐neutralizing anti‐HIV antibody 2F5 in plant suspension cells
Biotechnology Journal·2022· 4 citedOpen Access
Drug-Receptor Interactions
2021
Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor
Molecular Pharmacology·2021· 9 citedOpen Access
LEADS-FRAG: A Benchmark Data Set for Assessment of Fragment Docking Performance
Journal of Chemical Information and Modeling·2020· 15 cited
A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes
The Science of The Total Environment·2019· 51 citedOpen Access
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
Cell chemical biology·2019· 22 citedOpen Access
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Frequent Co-authors

Antti Poso(12), Philip Gribbon(10), Oliver Burk(8), Johanna Jyrkkärinne(7), Wolfgang Sippl(7), Paavo Honkakoski(7), Oliver Keminer(7), Matthias Schwab(6), Mathias Winterhalter(6), Thales Kronenberger(6), Cristina D. Cruz(5), Päivi Tammela(5), Carsten Wrenger(5), Manfred Köhler(4), Maija Lahtela‐Kakkonen(4), Gesa Witt(4), Jeanette Reinshagen(4), Maria Kuzikov(4), T. Szal(4), Laura Paunina(4)