John H.N. Meerman

Utrecht University — Netherlands

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

30h-index3.7kcitations122works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(20), Carcinogens and Genotoxicity Assessment(18), Estrogen and related hormone effects(16), DNA and Nucleic Acid Chemistry(14), DNA Repair Mechanisms(13)

Publications120 total

P18-71 Quantifying an Adverse Outcome Pathwayfor Parkinson's Disease: Putting Theory into Practice
Toxicology Letters·2025
P30-63 Refinement of a Workflow for Human Relevance Assessment of Adverse Outcome Pathways and Associated New Approach Methodologies
Toxicology Letters·2025
P01-03: Building an Excess Calcium-centric Adverse Outcome Pathway for Parkinsonian Motor Symptoms Related to Pesticides
Toxicology Letters·2023
A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer
Biochemical Pharmacology·2022· 7 citedOpen Access
Kinase Inhibitors Screen Tamoxifen Resistant Breast Cancer
Data Archiving and Networked Services (DANS)·2021Open Access
High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability
Archives of Toxicology·2019· 50 citedOpen Access
IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer
Oncogene·2018· 48 citedOpen Access
Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues
PLoS ONE·2014· 44 citedOpen Access
Abstract 4021: A kinome screen identifies SRPK1 to mediate breast cancer metastasis
Cancer Research·2014
Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation
BMC Cancer·2014· 79 citedOpen Access
Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity
Toxicological Sciences·2014· 89 citedOpen Access
β <sub>1</sub> Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer
Science Signaling·2014· 114 citedOpen Access
A physiologically relevant HepG2 cell based 3D cell culture model for high throughput toxicity studies
Toxicology Letters·2013
The Nuclear Factor κB Family Member RelB Facilitates Apoptosis of Renal Epithelial Cells Caused by Cisplatin/Tumor Necrosis Factor α Synergy by Suppressing an Epithelial to Mesenchymal Transition–Like Phenotypic Switch
Molecular Pharmacology·2013· 21 cited
Abstract 4349: Genome-wide kinase and phosphatase siRNA screen identifies clinically relevant targets in IGF1R signaling-mediated antiestrogen resistance in breast cancer.
Cancer Research·2013
Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells
Science Signaling·2013· 34 cited
Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening
PLoS ONE·2012· 34 citedOpen Access
TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells
Biochemical Pharmacology·2012· 78 cited
Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
Breast Cancer Research·2011· 167 citedOpen Access
539 Elevated IGF-1R signaling induces anti-estrogen resistance and provokes a switch from antagonistic to agonistic effect of tamoxifen in breast cancer cells
European Journal of Cancer Supplements·2010
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Frequent Co-authors

Nico Vermeulen(18), Bob van de Water(12), Jan N. M. Commandeur(11), Gerard J. Mulder(10), L.L. de Zwart(5), Marola M.H. van Lipzig(5), Erik H.J. Danen(5), Jeroen Kool(5), Sebastiaan van Liempd(5), Hubertus Irth(5), Hi̇lmi̇ Orhan(4), Lisa Fredriksson(4), Bram Herpers(4), Marjo de Graauw(4), R. C. A. Hermanns(4), Marja Moerkens(3), Hans de Bont(3), Leo Price(3), Erno Vreugdenhil(3), Giulia Benedetti(3)