Margarita Valhondo

Yale University — United States

Immunology and Microbiology · Life Sciences

7h-index219citations16works0.02yr avg
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Research Topics

Parasitic Infections and Diagnostics(5), Biochemical and Molecular Research(4), HIV/AIDS drug development and treatment(2), Colorectal Cancer Treatments and Studies(2), Radiation Effects and Dosimetry(2)

Publications16 total

Prodrug nanotherapy demonstrates <i>in vivo</i> anticryptosporidial efficacy in a mouse model of chronic <i>Cryptosporidium</i> infection
RSC Pharmaceutics·2024Open Access
Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead
ACS Medicinal Chemistry Letters·2021· 24 citedOpen Access
Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors
European Journal of Medicinal Chemistry·2019· 7 citedOpen Access
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-chlorobenzoic acid
2019
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid
2019
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)benzoic acid
2019
Understanding the structural basis of species selective, stereospecific inhibition for <i>Cryptosporidium</i> and human thymidylate synthase
FEBS Letters·2019· 5 citedOpen Access
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid
2019
Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening
Bioorganic & Medicinal Chemistry Letters·2019· 9 citedOpen Access
Electron spin resonance (ESR) spectroscopy study of cheese treated with accelerated electrons
Food Chemistry·2018· 24 citedOpen Access
A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors
Journal of the American Chemical Society·2016· 46 cited
Irregularities in enzyme assays: The case of macrophage migration inhibitory factor
Bioorganic & Medicinal Chemistry Letters·2016· 24 citedOpen Access
New Serotonin 5-HT<sub>1A</sub> Receptor Agonists Endowed with Antinociceptive Activity <i>in Vivo</i>
Journal of Medicinal Chemistry·2013· 30 citedOpen Access
Electron spin resonance (ESR) spectroscopy study of dry-cured ham treated with electron-beam
Food Chemistry·2012· 6 cited
New Serotonin 5-HT<sub>1A</sub> Receptor Agonists with Neuroprotective Effect against Ischemic Cell Damage
Journal of Medicinal Chemistry·2011· 44 citedOpen Access
Study of dry-cured ham e-beam treated by electron spin resonance (ESR) spectroscopy
Dialnet (Universidad de la Rioja)·2011

Frequent Co-authors

William L. Jorgensen(11), Karen S. Anderson(9), Daniel J. Czyzyk(8), José A. Cisneros(3), Marı́a Isabel Cambero Rodríguez(3), Michael J. Robertson(2), Isabel Marco(2), Mar Martín‐Fontecha(2), Henar Vázquez‐Villa(2), José A. Ramos(2), Bellinda Benhamú(2), María L. López-Rodrı́guez(2), Rosa Escudero(2), Raquel Velasco de Diego(2), Krasimir A. Spasov(2), Juan Antonio Ordóñez Pereda(2), Joaquín del Río Fernández(1), Anna M. Planas(1), Onintza Sagredo(1), Iván R. Torrecillas(1)