Adrien Herlédan

Inserm — France

Medicine · Health Sciences

16h-index875citations34works3.32yr avg
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Research Topics

Alzheimer's disease research and treatments(5), Biochemical and Molecular Research(5), Tuberculosis Research and Epidemiology(4), Advanced Biosensing Techniques and Applications(4), Computational Drug Discovery Methods(3)

Publications34 total

ERAP2 inhibitor −incorporated nanofibers: Characterization and biological assessment
International Journal of Pharmaceutics·2026Open Access
N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease
European Journal of Medicinal Chemistry·2024· 5 citedOpen Access
Small molecule MarR modulators potentiate metronidazole antibiotic activity in aerobic E. coli by inducing activation by the nitroreductase NfsA
Journal of Biological Chemistry·2024· 1 citedOpen Access
Insulin‐degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver
British Journal of Pharmacology·2024· 7 citedOpen Access
High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry
Cells·2023· 6 citedOpen Access
High-throughput quantitative screening of glucose-stimulated insulin secretion and insulin content using automated MALDI-TOF mass spectrometry
2023Open Access
Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses
European Journal of Medicinal Chemistry·2023· 16 citedOpen Access
CCDC 2143694: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases
Journal of Medicinal Chemistry·2022· 20 citedOpen Access
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
Angewandte Chemie·2022Open Access
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
Angewandte Chemie International Edition·2022· 21 citedOpen Access
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
Nature Communications·2022· 61 citedOpen Access
Identification of indole-based activators of insulin degrading enzyme
European Journal of Medicinal Chemistry·2021· 9 citedOpen Access
Rubrolone production by Dactylosporangium vinaceum: biosynthesis, modulation and possible biological function
Applied Microbiology and Biotechnology·2021· 8 cited
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor
Journal of Medicinal Chemistry·2021· 14 cited
Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening
European Journal of Medicinal Chemistry·2020· 22 citedOpen Access
Drug Target Engagement Using Coupled Cellular Thermal Shift Assay—Acoustic Reverse-Phase Protein Array
SLAS DISCOVERY·2019· 12 citedOpen Access
High‐Content Screening for Protein‐Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons
Current Protocols in Cell Biology·2019· 4 cited
Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening
European Journal of Medicinal Chemistry·2019· 21 citedOpen Access
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation
Acta Neuropathologica·2019· 64 citedOpen Access
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Frequent Co-authors

Benoît Déprez(26), Florence Leroux(22), Catherine Piveteau(15), Rebecca Deprez‐Poulain(10), Julie Charton(9), Damien Bosc(8), Nicolas Willand(8), Nathalie Hennuyer(7), François‐Xavier Cantrelle(7), Valérie Landry(7), Bart Staels(7), Alexandre Biela(7), Isabelle Duplan(6), Sandrine Warenghem(6), Julie Dumont(5), Marion Flipo(5), Ruben C. Hartkoorn(5), Wenguang Liang(4), Maxime Culot(4), Wei‐Jen Tang(4)