Tomohiro Morishige

Osaka University of Economics — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index647citations25works0.02yr avg
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Research Topics

Virus-based gene therapy research(9), RNA Interference and Gene Delivery(7), Immunotherapy and Immune Responses(6), Monoclonal and Polyclonal Antibodies Research(5), Cancer Research and Treatments(5)

Publications25 total

Noise Influence on Optical Multi-Eigenvalue Modulated Signal
2025
Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy
Cytokine·2012· 4 cited
Suppression of nanosilica particle-induced inflammation by surface modification of the particles
Archives of Toxicology·2012· 53 cited
Structure–activity relationship of T-cell receptors based on alanine scanning
Biochemical and Biophysical Research Communications·2011· 2 cited
Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation
Cytokine·2011· 3 cited
Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy
Molecular Therapy·2011· 36 citedOpen Access
Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties.
PubMed·2010· 24 cited
The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture
Biomaterials·2010· 149 cited
Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor
Biochemical and Biophysical Research Communications·2010· 12 cited
Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy
Biomaterials·2010· 16 cited
Titanium dioxide induces different levels of IL-1β production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B
Biochemical and Biophysical Research Communications·2010· 93 cited
Optimized PEGylated Adenovirus Vector Reduces the Anti-vector Humoral Immune Response against Adenovirus and Induces a Therapeutic Effect against Metastatic Lung Cancer
Biological and Pharmaceutical Bulletin·2010· 39 citedOpen Access
Adenovirus Vector Covalently Conjugated to Polyethylene Glycol with a Cancer-Specific Promoter Suppresses the Tumor Growth through Systemic Administration
Biological and Pharmaceutical Bulletin·2010· 10 citedOpen Access
Creation of lysine-deficient mutant lymphotoxin-α with receptor selectivity by using a phage display system
Biomaterials·2009· 13 cited
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models
International Immunopharmacology·2009· 3 cited
Creation of lysine-deficient mutant lymphotoxin-α with receptor selectivity by using phage display
Cytokine·2009
LIGHT protein suppresses tumor growth by augmentation of immune response
Immunology Letters·2009· 9 cited
Nanosilicas with different sizes and surface charges induce different profiles of cytokine production on macrophages
Toxicology Letters·2009
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis
Gene Therapy·2009· 48 cited
3P-081 ファージ表面提示法を用いたTNFR1指向性リンフォトキシンαの創製とその特性評価(蛋白質工学,進化工学,第46回日本生物物理学会年会)
生物物理·2008
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Frequent Co-authors

Naoki Okada(24), Yohei Mukai(23), Shinsaku Nakagawa(21), Yasuo Tsutsumi(17), Yasuo Yoshioka(14), Shin‐ichi Tsunoda(13), Aya Tanabe(11), Yasuo Yoshioka(9), Hikaru Watanabe(9), Xinglei Yao(9), Xinglei Yao(8), Shogo Narimatsu(8), Hiroyuki Mizuguchi(8), Yusuke Eto(7), Hiroshi Inakura(6), Shinji Ikemizu(3), Youko Monobe(2), Takayoshi Imazawa(2), Jianqing Gao(2), Ratima Asavatanabodee(2)