James A. Fornwald

GlaxoSmithKline (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.9kcitations29works0.02yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(7), Protein purification and stability(5), RNA and protein synthesis mechanisms(4), Monoclonal and Polyclonal Antibodies Research(4), Chemokine receptors and signaling(4)

Publications29 total

Gene Expression in Mammalian Cells Using BacMam, a Modified Baculovirus System
Methods in molecular biology·2016· 19 cited
High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome
Bioorganic & Medicinal Chemistry Letters·2015· 19 cited
Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation
PLoS ONE·2015· 19 citedOpen Access
Optimized procedures for producing biologically active chemokines
Protein Expression and Purification·2009· 22 cited
Gene Expression in Mammalian Cells Using BacMam, a Modified Baculovirus System
Humana Press eBooks·2007· 1 cited
Gene Expression in Mammalian Cells Using BacMam, a Modified Baculovirus System
Methods in molecular biology·2007· 38 cited
Oxazolidinones as novel human CCR8 antagonists
Bioorganic & Medicinal Chemistry Letters·2006· 22 citedOpen Access
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules
British Journal of Pharmacology·2006· 395 citedOpen Access
The peptidic urotensin‐II receptor ligand GSK248451 possesses less intrinsic activity than the low‐efficacy partial agonists SB‐710411 and urantide in native mammalian tissues and recombinant cell systems
British Journal of Pharmacology·2006· 36 citedOpen Access
BacMam Recombinant Baculoviruses in G Protein?Coupled Receptor Drug Discovery
Receptors and Channels·2004· 55 cited
BacMam Recombinant Baculoviruses in G Protein–Coupled Receptor Drug Discovery
Receptors and Channels·2004· 22 cited
Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
Molecular Pharmacology·2002· 647 cited
Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)
Journal of Medicinal Chemistry·2002· 309 citedOpen Access
Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system
Cytotechnology·2002· 27 citedOpen Access
Rapid Expression of Recombinant Proteins in Modified CHO Cells Using the Baculovirus System
2001· 2 cited
Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration
Journal of Biological Chemistry·2000· 121 citedOpen Access
The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase
Cellular Signalling·2000· 213 cited
Identification of a truncated form of the CC chemokine CK beta-8 demonstrating greatly enhanced biological activity.
PubMed·1998· 24 cited
Native Complex Formation between Apolipoprotein E Isoforms and the Alzheimer's Disease Peptide Aβ
Biochemistry·1996· 55 cited
Soluble Forms of the Human T Cell Receptor CD4 are Efficiently Expressed by Streptomyces lividans
Nature Biotechnology·1993· 38 cited
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Frequent Co-authors

Robert S. Ames(8), James J. Foley(6), Mary Brawner(6), Martin Rosenberg(4), John J. Trill(4), Quinn Lu(4), Ruth Lehr(3), James F. Callahan(3), Christina S. Imburgia(3), Charles P. Ordahl(3), Dulcie B. Schmidt(3), Henry M. Sarau(3), Parvathi Nuthulaganti(3), Zining Wu(3), Dean P. Taylor(3), Nicholas J. Laping(2), Anil Mathur(2), John D. Harling(2), Laramie M. Gaster(2), Barbara A. Olson(2)