Grace H. McGregor

Salk Institute for Biological Studies — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index822citations37works1.02yr avg
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Research Topics

Cancer, Lipids, and Metabolism(14), Cancer, Hypoxia, and Metabolism(9), Sphingolipid Metabolism and Signaling(6), Lipid metabolism and biosynthesis(6), Plant biochemistry and biosynthesis(5)

Publications37 total

Modeling lipid homeostasis using stable isotope tracing and flux analysis
Cell Metabolism·2026Open Access
Phase 1/2 study of spevatamig (PT886) in combination with gemcitabine plus nab-paclitaxel (GnP) in frontline (1L) treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC).
Journal of Clinical Oncology·2026
p53 increases phospholipid headgroup scavenging in senescence
Nature Cell Biology·2026· 1 citedOpen Access
1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
Cell chemical biology·2026Open Access
An open-label, multicenter, phase 1/2 study of peluntamig (PT217), an anti-DLL3/anti-CD47 bispecific antibody, in patients with DLL3-expressing cancers such as SCLC, LCNEC and EP-NEC (SKYBRIDGE study).
Journal of Clinical Oncology·2025· 1 cited
1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
2025· 1 citedOpen Access
Quantifying acyl-chain diversity in isobaric compound lipids containing monomethyl branched-chain fatty acids
Journal of Lipid Research·2024· 2 citedOpen Access
Modeling compound lipid homeostasis using stable isotope tracing
2024· 1 citedOpen Access
p53 enables phospholipid headgroup scavenging
2024· 3 citedOpen Access
Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
Science Advances·2023· 48 citedOpen Access
Supplementary Data from Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
2023Open Access
Data from Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
2023Open Access
Data from Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress
2023Open Access
Supplementary Figures 1-7 from Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress
2023Open Access
Supplementary Data from Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
2023Open Access
Supplementary Figures 1-7 from Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress
2023Open Access
Data from Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
2023Open Access
Data from Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress
2023Open Access
Supplementary Information from Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress
2023Open Access
Supplementary Information from Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress
2023Open Access
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Frequent Co-authors

Christian M. Metallo(15), David Sumpton(12), Jurre J. Kamphorst(12), Andrew D. Campbell(12), Owen J. Sansom(12), Gillian Mackay(9), Colin Nixon(8), Giovanny Rodriguez Blanco(8), Sara Zanivan(7), Irem Kaymak(7), Carina R. Maier(7), Werner Schmitz(7), Beatrice Dankworth(7), Carsten P. Ade(7), Susanne Walz(7), Madelon Paauwe(7), Charis Kalogirou(7), Hecham Marouf(7), Mathias T. Rosenfeldt(7), David M. Gay(7)