Christian M. Metallo

Salk Institute for Biological Studies — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

64h-index21.2kcitations307works2.92yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(121), Lung Cancer Treatments and Mutations(43), Mitochondrial Function and Pathology(42), Metabolomics and Mass Spectrometry Studies(33), Metabolism and Genetic Disorders(26)

Publications307 total

Limiting De Novo Lipogenesis Unlocks the Thermogenic Potential of Glucose in Brown Fat
2026Open Access
Modeling lipid homeostasis using stable isotope tracing and flux analysis
Cell Metabolism·2026Open Access
Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines
Cell Metabolism·2026· 1 citedOpen Access
p53 increases phospholipid headgroup scavenging in senescence
Nature Cell Biology·2026· 1 citedOpen Access
1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
Cell chemical biology·2026Open Access
Branched-chain fatty acids fire up the peroxisome
Cell Research·2025
Dietary serine supplementation exacerbates type 1 diabetes incidence and severity in non-obese diabetic (NOD) mice 3888
The Journal of Immunology·2025Open Access
Leveraging biochemical covariance to better understand biology
Molecular Cell·2025
Targeting serine dehydratase supports amino acid homeostasis and skin repair
2025Open Access
Enhancing cardiac serine biosynthesis mitigates the progression of dilated cardiomyopathy in mice
Metabolism·2025· 1 citedOpen Access
In vivo itaconate tracing reveals degradation pathway and turnover kinetics
Nature Metabolism·2025· 7 citedOpen Access
Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells
Antioxidants·2025· 2 citedOpen Access
Resuscitation from Hemorrhagic Shock with a Novel Protein Cocktail Restores Microvascular Perfusion and Protects Vital Organs
Shock·2025· 1 citedOpen Access
Author Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome
Nature·2025Open Access
Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer
2025Open Access
1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
2025· 1 citedOpen Access
Abstract 3025 Tracing and modeling compound lipid homeostasis to understand disease mechanisms
Journal of Biological Chemistry·2025Open Access
Fluoxetine promotes IL-10–dependent metabolic defenses to protect from sepsis-induced lethality
Science Advances·2025· 11 citedOpen Access
Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection
Nature Communications·2025· 11 citedOpen Access
In vivo itaconate tracing reveals degradation pathway and turnover kinetics
2025· 7 citedOpen Access
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Frequent Co-authors

Martina Wallace(13), Seth J. Parker(11), Matthew G. Vander Heiden(10), Gregory Stephanopoulos(8), Courtney R. Green(8), Anne N. Murphy(8), Karsten Hiller(7), Thekla Cordes(7), Ajit S. Divakaruni(7), María T. Díaz‐Meco(6), Jorge Moscat(6), Mehmet G. Badur(5), Michael Karin(4), Ángeles Durán(4), Katherine Mattaini(3), Shawn M. Davidson(3), Alexandra Grassian(3), John M. Asara(3), Alan Saghatelian(3), Pedro Cabrales(3)