Mark P. Murphy

Royal College of Surgeons in Ireland — Ireland

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index1.4kcitations50works1.22yr avg
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Research Topics

Protease and Inhibitor Mechanisms(13), Cystic Fibrosis Research Advances(10), Peptidase Inhibition and Analysis(9), Neonatal Respiratory Health Research(7), Bacterial biofilms and quorum sensing(5)

Publications49 total

32 Assessment of the changes to the respiratory tract microbiome of CF patients 4 years on ETI
Journal of Cystic Fibrosis·2025
175 Do CT images accurately identify inflammatory ‘hotspots’ in the CF lung?
Journal of Cystic Fibrosis·2025
179 Long term effects of elexacaftor/tezacaftor/ivacaftor on airway and systemic inflammation in cystic fibrosis over a five-year period
Journal of Cystic Fibrosis·2025
Severe Alpha-1 antitrypsin deficiency detected via Family Screening— Are never-smokers disease-free?
2025
Late Breaking Abstract - Real-world evidence for severe Alpha-1 Antitrypsin Deficiency: Life-years gained for augmentation therapy versus standard care
2025
Late Breaking Abstract - Targeting senescence to reduce inflammation in alpha-1 antitrypsin deficiency (AATD)
2025
Seasonal Changes in Circulating Alpha-1 Antitrypsin Are Altered by Sex and Genetic Deficiency
American Journal of Respiratory and Critical Care Medicine·2025
An update on targeting airway inflammation in cystic fibrosis
Expert Review of Respiratory Medicine·2025· 1 cited
Evaluation of Longitudinal Lung Function Decline Through Spirometry, CT Imaging and Oscillometry in MZ Alpha-1 Antitrypsin Deficiency Individuals, With Respect to Smoking Status, Reason for Referral, Age, and Gender
American Journal of Respiratory and Critical Care Medicine·2025
Optimising bronchoalveolar lavage: lessons from alpha-1 antitrypsin deficiency
Thorax·2024· 3 citedOpen Access
Late Breaking Abstract - Severe alpha-1 antitrypsin deficiency is associated with increased expression of CD8+ T cell markers
2024
Citrullination, a novel posttranslational modification of elastin, is involved in COPD pathogenesis
American Journal of Physiology-Lung Cellular and Molecular Physiology·2024· 5 cited
Neutrophil-Derived Peptidyl Arginine Deiminase Activity Contributes to Pulmonary Emphysema by Enhancing Elastin Degradation
The Journal of Immunology·2024· 7 citedOpen Access
Long-term follow-up of Pi*ZZ alpha-1 antitrypsin deficient patients receiving intravenous alpha-1 antitrypsin augmentation therapy
2023· 1 cited
Optimising research bronchoalveolar lavage in COPD and alpha-1 antitrypsin deficiency
2023· 1 cited
Cellular stress and senescence in alpha-1 antitrypsin deficiency: therapeutic opportunities
2023
Safety and Reactogenicity of COVID-19 Vaccination in Severe Alpha-1 Antitrypsin Deficiency
Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation·2023· 3 citedOpen Access
Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline—A Multinational Registry Analysis
American Journal of Respiratory and Critical Care Medicine·2023· 46 citedOpen Access
Effect of elexacaftor/tezacaftor/ivacaftor on airway and systemic inflammation in cystic fibrosis
Thorax·2023· 102 citedOpen Access
Peptidyl-arginine deiminases – neutrophil derived proteins as anti-Pseudomonas aeruginosa agents in patients with cystic fibrosis
05.01 - Airway pharmacology and treatment·2023
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Frequent Co-authors

Noel G. McElvaney(28), Tomás P. Carroll(18), Emer P. Reeves(15), Oliver J. McElvaney(13), Cedric Gunaratnam(11), D. Fraughen(10), Oisín F. McElvaney(9), Emma Leacy(8), Malcolm Herron(7), Suzanne Roche(7), Michelle Casey(6), R.C. Heeney(6), Karen McQuillan(5), Emma Caraher(5), Gerry McElvaney(5), Paula Meleady(4), Michael Henry(4), Padraig Hawkins(4), Natalie McEvoy(3), Jennifer Clarke(3)