Yuan-li Ai

Xiamen University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index1.4kcitations8works22.02yr avg
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Research Topics

Inflammasome and immune disorders(4), Cell death mechanisms and regulation(2), Nuclear Receptors and Signaling(2), Cancer-related molecular mechanisms research(1), Autophagy in Disease and Therapy(1)

Publications8 total

Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage
Signal Transduction and Targeted Therapy·2025Open Access
cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models
Journal of Clinical Investigation·2025· 8 citedOpen Access
Full-length GSDME mediates pyroptosis independent from cleavage
Nature Cell Biology·2024· 58 cited
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Cell Research·2023· 89 citedOpen Access
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Cell Research·2021· 365 citedOpen Access
Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis
Oncogene·2020· 79 citedOpen Access
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 
Cell Research·2018· 638 citedOpen Access
Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
Molecular Cell·2018· 138 citedOpen Access

Frequent Co-authors

Hang‐zi Chen(8), Qiao Wu(7), Liu-zheng Wu(4), Qi-Tao Chen(4), Bo Zhou(3), Fu-Nan Li(3), Wenbin Hong(3), Bo Zhou(2), Jia-yuan Zhang(2), Kang Cheng(2), Ru-yue Sun(2), Dawang Zhou(2), Fan-jian Liu(2), Zhi‐Hong Jiang(2), Weijia Wang(2), Yun‐Feng Guan(2), Xian-shuo Liu(1), Jiahuai Han(1), Bao-rui Wang(1), Xiao-Xue Li(1)