Biochemistry, Genetics and Molecular Biology · Life Sciences
13h-index1.6kcitations29works0.02yr avg
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Research Topics
Retinal Development and Disorders(17), Photoreceptor and optogenetics research(11), Receptor Mechanisms and Signaling(9), Cellular transport and secretion(3), Endoplasmic Reticulum Stress and Disease(3)
Publications29 total
Journal of Neuroscience·2014· 37 citedOpen Access
Eliminating Chromophore Binding Via Vitamin A Deprivation Results In Different Outcomes In Two Transgenic X. Laevis Models Of Retinitis Pigmentosa
Investigative Ophthalmology & Visual Science·2011
Novel Self-Delivering RNAi Compounds (sd-rxRNATM) Demonstrate Robust Ocular Cell Uptake in vitro and in vivo
2010
Activation of the Unfolded Protein Response in a Rat Model of ADRP
Investigative Ophthalmology & Visual Science·2010
Dose-Dependent Differential Effect of HDAC Inhibitors on Yields of Folded P23H and WT Rhodopsin
Investigative Ophthalmology & Visual Science·2010· 5 cited
The Light Activated Conformations of Rhodopsin Glycosylation Mutants T4K and T17M Are Unstable and Toxic to Photoreceptors
2010
Role of Heat Shock Response in Rhodopsin Folding
Investigative Ophthalmology & Visual Science·2010
The Effect of Valproic Acid in Mouse Models of RP
Investigative Ophthalmology & Visual Science·2010· 6 cited
Proceedings of the National Academy of Sciences·2010· 285 citedOpen Access
Journal of Biological Chemistry·2009· 39 citedOpen Access
Investigative Ophthalmology & Visual Science·2008· 68 cited
Effect of Small Molecule Inhibitors on Cellular Pathways That Control the Fate of P23H Rhodopsin
Investigative Ophthalmology & Visual Science·2008
High-Throughput Virtual Screening and Identification of a Pharmacological Chaperone for Misfolded Rhodopsin
Investigative Ophthalmology & Visual Science·2007
Production of a high maltose-forming, hyperthermostable and Ca 2+ - independent amylopullulanase by an extreme thermophile Geobacillus thermoleovorans in submerged fermentation
2006· 12 cited
Gene Therapy in the Three Month–Old rd12 Mouse, a Model for Mid–Course RPE65 Leber Congenital Amaurosis, Leads to Long–Term Vision Restoration
Investigative Ophthalmology & Visual Science·2006
Intracellular Fate of Wild–Type and P23H Rhodopsin
Investigative Ophthalmology & Visual Science·2005
Long Term Vision Restoration by Gene Therapy in the rd12 Mouse Model of RPE65 Leber Congenital Amaurosis
Investigative Ophthalmology & Visual Science·2005· 1 cited
Thermal Stability of Pharmacologically–Rescued Mutant Rhodopsins Correlates With Their Autosomal Dominant Retinitis Pigmentosa Phenotype
Investigative Ophthalmology & Visual Science·2005
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Frequent Co-authors
S. Kaushal(14), Shalesh Kaushal(9), J. Hugh McDowell(8), William W. Hauswirth(7), Bo Chang(6), Steven Nusinowitz(6), Mark P. Krebs(6), Jijing Pang(5), Ritu Malhotra(3), T. Satyanarayana(3), Orson L. Moritz(3), Marina S. Gorbatyuk(2), Tessa Knox(2), Oleg S. Gorbatyuk(2), Jonathan H. Lin(2), Nicholas Muzyczka(2), Alfred S. Lewin(2), Norman L. Hawes(2), Jie Li(2), John R. Heckenlively(2)