Philip D. Greenberg

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa — South Africa

Medicine · Health Sciences

85h-index32.3kcitations432works3.92yr avg
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Research Topics

CAR-T cell therapy research(222), Immunotherapy and Immune Responses(161), Immune Cell Function and Interaction(138), T-cell and B-cell Immunology(76), Virus-based gene therapy research(62)

Publications432 total

Guidelines for T cell nomenclature
Nature reviews. Immunology·2025· 11 citedOpen Access
344 Safety and efficacy of targeting the p14ARF tumor suppressor using TCR T-cell therapy
Regular and Young Investigator Award Abstracts·2025Open Access
364 Systems immunology-guided <i>in vivo</i> CRISPR screens reveal a multifunctional E3 ligase that enhances adoptive T cell therapy for solid tumors
Regular and Young Investigator Award Abstracts·2025Open Access
339 Engineered T cell therapy combined with PD-1, Lag-3 and Tim-3 checkpoint inhibition promotes pro-inflammatory CD4 T cell differentiation in an ovarian cancer mouse model
Regular and Young Investigator Award Abstracts·2025Open Access
345 Discovery and characterization of human T cell receptors that recognize tumor-associated antigens derived from tumor suppressors p16INK4A and p14ARF
Regular and Young Investigator Award Abstracts·2025Open Access
Triple checkpoint blockade, but not anti-PD-1 alone, enhances engineered adoptive T cell therapy in a mouse model of advanced ovarian cancer 2090
The Journal of Immunology·2025Open Access
A TGF-βR/IL-2R immunomodulatory fusion protein transforms immunosuppression into T cell activation to enhance adoptive T cell therapy
Proceedings of the National Academy of Sciences·2025Open Access
Triple checkpoint blockade of PD-1, Tim-3, and Lag-3 enhances adoptive T cell immunotherapy in a mouse model of ovarian cancer
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma
2025· 1 citedOpen Access
A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence
Nature Communications·2025· 4 citedOpen Access
Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials
Journal for ImmunoTherapy of Cancer·2025· 4 citedOpen Access
Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition
Science·2025· 33 cited
A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands
2025Open Access
Abstract 1071: Online resources from the Allen Institute for Immunology: longitudinal profiling of multiple myeloma treatment and the Human Immune System Explorer platform
Cancer Research·2025
Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy
Blood·2025· 9 citedOpen Access
APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence
Nature Communications·2025· 5 citedOpen Access
Phase I study of autologous CD8+ and CD4+ transgenic T cells expressing high-affinity KRAS G12V mutation-specific T cell receptors (FH-A11KRASG12V-TCR) in patients with metastatic pancreatic, colorectal, and non-small cell lung cancers with KRAS G12V mutations.
Journal of Clinical Oncology·2025· 1 cited
APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence
2025Open Access
Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence
2024Open Access
Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity
Cancer Cell·2024· 44 citedOpen Access
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Frequent Co-authors

Stanley R. Riddell(16), Cassian Yee(6), Mark M. Davis(5), Stephen J. Forman(5), Ingunn M. Stromnes(5), Raphaël Gottardo(4), William Ho(4), Brian G. Till(4), Michael C. Jensen(4), Jinjuan Wang(4), Andrew Raubitschek(4), Oliver W. Press(4), Joseph N. Blattman(4), Hieu Nguyen(4), Thomas M. Schmitt(4), M. Jean Gilbert(3), Kristin G. Anderson(3), Peter P. Lee(3), Xiaojun Qian(3), Scott E. James(3)