István Tombácz

University of Pennsylvania — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index2.5kcitations20works1.02yr avg
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Research Topics

RNA Interference and Gene Delivery(9), Immunotherapy and Immune Responses(7), SARS-CoV-2 and COVID-19 Research(5), HIV Research and Treatment(4), RNA Research and Splicing(4)

Publications20 total

Design and Development of <scp>mRNA</scp> Vaccines to Combat the <scp>COVID</scp> ‐19 Pandemic
2024· 1 cited
Development of an mRNA-lipid nanoparticle vaccine against Lyme disease
Molecular Therapy·2023· 70 citedOpen Access
Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice
Science Translational Medicine·2023· 119 citedOpen Access
CAR T Cells Produced in vivo to Treat Cardiac Injury
2023· 19 cited
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Immunity·2022· 66 citedOpen Access
Author Correction: Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
npj Vaccines·2021· 4 citedOpen Access
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Immunity·2021· 662 citedOpen Access
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
Molecular Therapy·2021· 243 citedOpen Access
Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
npj Vaccines·2021· 82 citedOpen Access
Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
2020· 25 citedOpen Access
Vaccination with Messenger RNA: A Promising Alternative to DNA Vaccination
Methods in molecular biology·2020· 54 cited
A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice
Immunity·2020· 376 citedOpen Access
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
Proceedings of the National Academy of Sciences·2020· 169 citedOpen Access
Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques
Molecular Therapy — Nucleic Acids·2019· 103 citedOpen Access
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
The Journal of Experimental Medicine·2018· 502 citedOpen Access
Generation of a CTO gene mutant Pseudorabies virus
Transcriptomics Open Access·2015
High Fcp1 phosphatase activity contributes to setting an intense transcription rate required in Drosophila nurse and follicular cells for egg production
Gene·2012· 1 cited
The RNA Pol II CTD phosphatase Fcp1 is essential for normal development in Drosophila melanogaster
Gene·2009· 16 cited
GAL4 induces transcriptionally active puff in the absence of dSAGA- and ATAC-specific chromatin acetylation in the Drosophila melanogaster polytene chromosome
Chromosoma·2009· 7 cited
Misregulated RNA Pol II C-terminal domain phosphorylation results in apoptosis
Cellular and Molecular Life Sciences·2009· 10 citedOpen Access

Frequent Co-authors

Ying K. Tam(13), Norbert Pardi(13), Drew Weissman(12), Hiromi Muramatsu(8), Barbara L. Mui(7), Katalin Karikó(6), Barton F. Haynes(6), Michael J. Hogan(5), David C. Montefiori(5), Kevin O. Saunders(5), Robert Parks(5), Brian T. Gaudette(4), Dorottya Laczkó(4), Paulo J.C. Lin(4), Florian Krammer(4), David Allman(4), Michela Locci(4), Richard M. Scearce(4), Mark G. Lewis(4), Zekun Mu(4)