Nicholas Shinners

Nurix (United States) — United States

Medicine · Health Sciences

12h-index959citations27works0.02yr avg
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Research Topics

CAR-T cell therapy research(10), NF-κB Signaling Pathways(8), Immune Cell Function and Interaction(7), T-cell and B-cell Immunology(5), Immunotherapy and Immune Responses(4)

Publications26 total

361 Universal expansion of CBL-B-inhibited tumor infiltrating lymphocytes, DeTIL-0255, from women with ovarian cancer: Process validation
Regular and Young Investigator Award Abstracts·2022Open Access
Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies
Leukemia·2019· 78 citedOpen Access
MyD88/CD40 Enhanced CD19-Specific CAR-T Cells Maintain Therapeutic Efficacy Following Resolution of Cytokine-Related Toxicity Using Inducible Caspase-9
Blood·2017
Single-Cell Multiplex Proteomics Reveals Synergistic Impact of Antigen and Rimiducid-Dependent Stimulatory Signals on Promoting Polyfunctional GoCAR-T Cells Targeting Prostate Stem Cell Antigen (PSCA)
Blood·2017· 1 cited
Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40
Molecular Therapy·2017· 103 citedOpen Access
Tonic B-cell receptor signaling in diffuse large B-cell lymphoma
Blood·2017· 114 citedOpen Access
Inducible MyD88/CD40 (iMC) Costimulation Provides Ligand-Dependent Tumor Eradication By CD123-Specific Chimeric Antigen Receptor T Cells
Blood·2016· 2 cited
Inducible MyD88/CD40 to allow rimiducid-dependent activation for control of proliferation and survival of chimeric antigen receptor (CAR) T cells targeting prostate stem cell antigen (PSCA).
Journal of Clinical Oncology·2016· 2 cited
Inducible MyD88/CD40 Allows Rimiducid-Dependent Activation to Control Proliferation and Survival of Chimeric Antigen Receptor-Modified T Cells
Blood·2015· 2 cited
Inducible MyD88/CD40 Allows AP1903-Dependent Costimulation to Control Proliferation and Survival of Chimeric Antigen Receptor-Modified T Cells
Blood·2014· 2 cited
The B-Cell Receptor Is Required for Optimal Viability, Growth, and Chemotherapy Resistance of Diffuse Large B-Cell Lymphoma Cell Lines of the Germinal Center B-Cell Subtype
Blood·2014· 4 cited
Genome-wide siRNA screen for mediators of NF-κB activation
Proceedings of the National Academy of Sciences·2012· 110 citedOpen Access
Canonical NF-κB Activation Is Essential for Epstein-Barr Virus Latent Membrane Protein 1 TES2/CTAR2 Gene Regulation
Journal of Virology·2011· 49 cited
BCR mediated c-Rel induction facilitates NF-{kappa}B2 and RelB expression
The Journal of Immunology·2010
BCR mediated c-Rel induction facilitates NF-κB2 and RelB expression (84.22)
The Journal of Immunology·2010
B Cell Receptor-Mediated Sustained c-Rel Activation Facilitates Late Transitional B Cell Survival through Control of B Cell Activating Factor Receptor and NF-κB2
The Journal of Immunology·2009· 51 citedOpen Access
BAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development
Humana Press eBooks·2009· 5 cited
IRF7 activation by Epstein–Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3
Proceedings of the National Academy of Sciences·2008· 52 citedOpen Access
Bruton’s tyrosine kinase mediates NF-κB activation and B cell survival by B cell-activating factor receptor of the TNF-R family
The Journal of Immunology·2007· 2 cited
Bruton’s Tyrosine Kinase Mediates NF-κB Activation and B Cell Survival by B Cell-Activating Factor Receptor of the TNF-R Family
The Journal of Immunology·2007· 113 citedOpen Access
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Frequent Co-authors

Wasif N. Khan(12), Kristen L. Hoek(9), Aaron E. Foster(8), Aruna Mahendravada(8), David M. Spencer(8), Gianluca Carlesso(7), Iris Castro(7), Kevin M. Slawin(7), Rachel M. Gerstein(5), An Lu(5), John Lowe(4), Jeannette Crisostomo(4), Peter S. Chang(4), James B. Petro(3), Benjamin E. Gewurz(3), Elliott Kieff(3), Mariam Khalil(3), Éva Morschl(3), Joanne Shaw(3), Sunandan Saha(3)