Patrick Ryan Potts

St. Jude Children's Research Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index4.8kcitations71works3.82yr avg
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Research Topics

Ubiquitin and proteasome pathways(31), Protein Degradation and Inhibitors(18), Immunotherapy and Immune Responses(12), RNA Interference and Gene Delivery(12), DNA Repair Mechanisms(7)

Publications71 total

A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
Cell Reports·2025Open Access
Load and lock: An emerging class of therapeutics that influence macromolecular dissociation
Science·2025· 8 cited
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation
Nature Communications·2025· 4 citedOpen Access
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues
Molecular Cell·2025
Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors
Acta Neuropathologica Communications·2025· 1 citedOpen Access
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Journal of the American Chemical Society·2025· 4 cited
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
2025· 9 citedOpen Access
A Cancer-Specific Antigen Drives Histone Acetylation by Stabilizing the Acetyltransferases
2025· 1 cited
VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation
Cell chemical biology·2025· 8 cited
Molecular glue unexpectedly mimics the effect of cancer mutations
Nature·2025· 1 cited
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
2025· 2 citedOpen Access
LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation
2024Open Access
VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation
2024Open Access
Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity
Cell chemical biology·2024
RNATACs: Multispecific small molecules targeting RNA by induced proximity
Cell chemical biology·2024· 21 citedOpen Access
Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors
2024Open Access
TAC‐tics for Leveraging Proximity Biology in Drug Discovery
ChemBioChem·2023· 29 cited
Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction
RSC Chemical Biology·2023· 68 citedOpen Access
High throughput E3 ligase degron binding assays for novel PROTAC ligand discovery
Methods in enzymology on CD-ROM/Methods in enzymology·2022· 4 cited
Target and tissue selectivity of PROTAC degraders
Chemical Society Reviews·2022· 247 cited
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Frequent Co-authors

Klementina Fon Tacer(12), Seung Wook Yang(7), Sajjan Koirala(7), Jaeki Min(6), Hongtao Yu(5), Jonathon Klein(5), Anna K. Lee(4), Ramya Ravichandran(4), Heather Tillman(4), Shondra M. Pruett‐Miller(4), Kate S. Ashton(4), Jenny L. Weon(3), Robert G. Guenette(3), Mohanish Deshmukh(3), Anand Mayasundari(3), Taosheng Chen(3), Richard Lee(3), Zoran Ranković(3), Melissa J. Oatley(3), Tessa Lord(3)