Sylwia Huber

Roche (Switzerland) — Switzerland

Medicine · Health Sciences

18h-index1.7kcitations51works2.32yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(10), Neuroscience and Neuropharmacology Research(8), Cannabis and Cannabinoid Research(6), Receptor Mechanisms and Signaling(6), RNA Interference and Gene Delivery(5)

Publications51 total

Exploring β-catenin and TCF4 interaction in complex environments by means of novel biosensing platform focal molography
PLoS ONE·2025Open Access
Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche’s Internal Monoacylglycerol Lipase Program
ACS Chemical Neuroscience·2025
Structure-Guided Discovery of <i>cis</i>-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors
Journal of Medicinal Chemistry·2024· 7 citedOpen Access
Propensities of Fatty Acid-Modified ASOs: Self-Assembly vs Albumin Binding
Bioconjugate Chemistry·2023· 11 cited
CCDC 2201760: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain
European Journal of Medicinal Chemistry·2022· 13 citedOpen Access
Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies
Acta Neuropathologica Communications·2022· 18 citedOpen Access
CCDC 1923120: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
Chemical Science·2022· 35 citedOpen Access
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy
Acta Neuropathologica·2021· 149 citedOpen Access
Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP
Journal of Structural Biology·2020· 7 citedOpen Access
Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization
Angewandte Chemie International Edition·2020· 27 cited
Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides
European Journal of Pharmaceutics and Biopharmaceutics·2020· 52 cited
Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization
Angewandte Chemie·2020· 5 cited
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
Journal of the American Chemical Society·2020· 47 citedOpen Access
Reply to Alarcon and Borroto: Small molecule AX-024 reduces T cell proliferation independently of CD3ε-Nck1 interaction at SH3.1
Journal of Biological Chemistry·2020Open Access
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
2020· 2 citedOpen Access
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
2020· 5 citedOpen Access
Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain
Journal of Biological Chemistry·2020· 15 citedOpen Access
Drug Derived Fluorescent Probes for the Specific Visualization of Cannabinoid Type 2 Receptor - A Toolbox Approach
2019Open Access
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Frequent Co-authors

Melanie N. Hug(16), Arne C. Rufer(16), Eric A. Kusznir(13), Wolfgang Guba(12), Mario van der Stelt(11), Uwe Grether(11), Anto Pavlovic(10), Michael Honer(10), Jürg Gertsch(10), Roman C. Sarott(9), Patrick Pfaff(9), Claudia Korn(9), Thais Gazzi(9), Benjamin Brennecke(9), Kenneth Atz(9), Marie Weise(9), Yelena Mostinski(9), Tamara Miljuš(9), Elisabeth A. Zirwes(9), Anja Osterwald(9)