David A. Beebe

Pfizer (United States) — United States

Medicine · Health Sciences

18h-index5.1kcitations31works0.02yr avg
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Research Topics

Pancreatic function and diabetes(7), Peroxisome Proliferator-Activated Receptors(6), Aldose Reductase and Taurine(6), Diabetes Treatment and Management(5), Cannabis and Cannabinoid Research(5)

Publications31 total

GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner
Cellular and Molecular Gastroenterology and Hepatology·2023· 8 citedOpen Access
De novo lipogenesis is essential for platelet production in humans
Nature Metabolism·2020· 47 cited
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Journal of Medicinal Chemistry·2020· 29 cited
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Cellular and Molecular Gastroenterology and Hepatology·2020· 89 citedOpen Access
The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes
Metabolism·2019· 26 cited
PS-109-Partial inhibition of de novo lipogenesis with the acetyl-CoA carboxylase inhibitor PF-05221304 does not increase circulating triglycerides in humans and is sufficient to lower steatosis in rats
Journal of Hepatology·2019· 2 cited
Combined Exercise Training and Sodium‐glucose Cotransporter 2 Inhibition Improves Glycemic Control and Exercise Tolerance When Compared to Pharmacotherapy Alone in a Model of Type 2 Diabetes
The FASEB Journal·2018
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Journal of Medicinal Chemistry·2017· 49 citedOpen Access
Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
Journal of Medicinal Chemistry·2013· 47 citedOpen Access
Effects of age on noninvasive assessments of vascular function in nonhuman primates: implications for translational drug discovery
Journal of Translational Medicine·2013· 6 citedOpen Access
Abstract 8926: Rosiglitazone Acutely Improves Flow Mediated Dilation and Favorably Alters Endothelial Microparticle and Progenitor Cell Numbers in Euglycemic, Senescent Monkeys
Circulation·2011
Abstract 16821: Reductions in Vascular Function Correlate with Age in a Novel Non-Human Primate Model for Assessment of Vascular Health
Circulation·2011· 1 cited
1-((3S,4S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes
Bioorganic & Medicinal Chemistry Letters·2011· 20 citedOpen Access
Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus
MedChemComm·2011· 68 cited
The Effect on Final Bond Strength of Bracket Manipulation Subsequent To Initial Positioning
PhDT·2011
Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
Bioorganic & Medicinal Chemistry Letters·2009· 80 citedOpen Access
Failure rates and survival analysis of maxillary expansion appliances: a 24-year retrospective analysis.
PubMed·2009
Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of Type 2 diabetes
Bioorganic & Medicinal Chemistry Letters·2009· 8 citedOpen Access
A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2<i>H</i>-pyridazin-3-one and Congeners
Journal of Medicinal Chemistry·2005· 65 citedOpen Access
X-Ray Crystallographic and Kinetic Studies of Human Sorbitol Dehydrogenase
Structure·2003· 98 citedOpen Access
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Frequent Co-authors

Peter J. Oates(13), Banavara L. Mylari(8), Trenton T. Ross(8), Jeffrey A. Pfefferkorn(7), William P. Esler(7), James B. Coutcher(7), William J. Zembrowski(7), Boris A. Chrunyk(4), John W. Benbow(4), Edward L. Conn(4), Michael S. Dina(4), Shawn D. Doran(4), Andrew H. Smith(4), Thomas Pauly(3), J.L. Ekstrom(3), R. Madura(3), Timothy A. Subashi(3), Collin Crowley(3), Kenneth L. Kelly(3), Meihua Tu(3)