Elisabeth Klaasse

Leiden University — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index453citations14works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(10), Cardiac electrophysiology and arrhythmias(7), Adenosine and Purinergic Signaling(6), Ion channel regulation and function(5), Neuropeptides and Animal Physiology(2)

Publications14 total

Removal of Human Ether-à-go-go Related Gene (hERG) K<sup>+</sup> Channel Affinity through Rigidity: A Case of Clofilium Analogues
Journal of Medicinal Chemistry·2013· 32 citedOpen Access
Allosteric modulators of the hERG K+ channel
Toxicology and Applied Pharmacology·2013· 23 citedOpen Access
Strategies To Reduce hERG K<sup>+</sup> Channel Blockade. Exploring Heteroaromaticity and Rigidity in Novel Pyridine Analogues of Dofetilide
Journal of Medicinal Chemistry·2013· 37 citedOpen Access
Cover Picture: Understanding of Molecular Substructures that Contribute to hERG K<sup>+</sup> Channel Blockade: Synthesis and Biological Evaluation of E‐4031 Analogues (ChemMedChem 1/2012)
ChemMedChem·2011· 9 cited
Understanding of Molecular Substructures that Contribute to hERG K<sup>+</sup> Channel Blockade: Synthesis and Biological Evaluation of E‐4031 Analogues
ChemMedChem·2011· 19 cited
Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor
Biochemical Pharmacology·2010· 13 citedOpen Access
Prospective Validation of a Comprehensive In silico hERG Model and its Applications to Commercial Compound and Drug Databases
ChemMedChem·2010· 106 cited
Exploring Chemical Substructures Essential for hERG K<sup>+</sup> Channel Blockade by Synthesis and Biological Evaluation of Dofetilide Analogues
ChemMedChem·2009· 26 cited
Non-ribose ligands for the human adenosine A1 receptor
Leiden Repository (Leiden University)·2008Open Access
Internalization and desensitization of adenosine receptors
Purinergic Signalling·2007· 119 citedOpen Access
Allosteric modulators affect the internalization of human adenosine A1 receptors
European Journal of Pharmacology·2005· 20 cited
Non-ribose ligands for the human adenosine A1 receptor. Affinities, activities, allosteric modulation and internalization
2004
Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi α-subunits
European Journal of Pharmacology·2004· 5 cited
<i>N</i><sup>6</sup>-Cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a Very Selective Agonist with High Affinity for the Human Adenosine A<sub>1</sub> Receptor
Journal of Medicinal Chemistry·2003· 44 citedOpen Access

Frequent Co-authors

Adriaan P. IJzerman(13), Johannes Brussee(5), Margot W. Beukers(4), Willem J. de Grip(2), Shagufta Shagufta(2), João F. S. Carvalho(2), Julien Louvel(2), Zhiyi Yu(2), Sophie Roerink(2), M. Viļums(2), Jeroen Overman(2), Olaf Scheel(2), Munikumar Reddy Doddareddy(1), Andreas Bender(1), Martin J. Wanner(1), Jacobien K. von Frijtag Drabbe Künzel(1), Gerrit‐Jan Koomen(1), Maarten L. J. Doornbos(1), Zhiyi Yu(1), Marjolein Soethoudt(1)