Henning Gram Hansen

Novo Nordisk Foundation — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.2kcitations25works0.02yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(12), Endoplasmic Reticulum Stress and Disease(7), Virus-based gene therapy research(4), Protein purification and stability(4), Heme Oxygenase-1 and Carbon Monoxide(4)

Publications24 total

Transient Gene Expression‐Based Protein Production in Recombinant Mammalian Cells
2019· 6 cited
Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering
ACS Synthetic Biology·2019· 55 cited
Chromophore pre-maturation for improved speed and sensitivity of split-GFP monitoring of protein secretion
Scientific Reports·2019· 16 citedOpen Access
Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles
Metabolic Engineering·2018· 55 cited
Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept
Biotechnology Journal·2018· 22 citedOpen Access
A combinatorial use of titer and titer normalized to confluence as early reporters allows for selecting Chinese Hamster Ovary cell clones with high volumetric productivity of Etanercept
2018
Droplet microfluidics and split-GFP complementation enable selection of Chinese hamster ovary cells with high specific productivity of therapeutic glycoproteins
2017
Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Biotechnology Advances·2016· 71 cited
Case study on human α1‐antitrypsin: Recombinant protein titers obtained by commercial ELISA kits are inaccurate
Biotechnology Journal·2016· 8 citedOpen Access
Celigo-based cell-counting and viability assay for mammalian cells
Protocol Exchange·2016· 1 citedOpen Access
A stochastic model to study genetic and metabolic effects on N-linked protein glycosylation
2016
Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells
Scientific Reports·2015· 29 citedOpen Access
A novel low-parameter computational model to aid in-silico glycoengineering
BMC Proceedings·2015Open Access
A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering
Metabolic Engineering·2015· 101 citedOpen Access
Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool
Biotechnology and Bioengineering·2014· 191 citedOpen Access
Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262
Bioscience Reports·2014· 9 citedOpen Access
GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum
Free Radical Biology and Medicine·2014· 149 cited
Endoplasmic reticulum: Reduced and oxidized glutathione revisited
Journal of Cell Science·2013· 160 citedOpen Access
Hyperactivity of the Ero1α Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response
Journal of Biological Chemistry·2012· 59 citedOpen Access
Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice
Molecular Cell·2012· 114 citedOpen Access
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Frequent Co-authors

Helene Faustrup Kildegaard(12), Gyun Min Lee(7), Christian Appenzeller‐Herzog(5), Lars Ellgaard(5), Mikael Rørdam Andersen(5), Anders Holmgaard Hansen(4), Johnny Arnsdorf(4), Nathan E. Lewis(4), Nuša Pristovšek(4), Stefan Kol(4), Magnus Lundqvist(3), Johan Rockberg(3), Julia Birk(2), Thomas Ramming(2), Philipp N. Spahn(2), Jonas Damgård Schmidt(2), Cecilie L. Søltoft(2), Saranya Nallapareddy(2), Lise Marie Grav(2), Anne Julie Overgaard(2)