Wayne Vuong

Massachusetts Institute of Technology — United States

Medicine · Health Sciences

10h-index925citations15works2.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(10), Animal Virus Infections Studies(6), Computational Drug Discovery Methods(4), Virus-based gene therapy research(3), Viral gastroenteritis research and epidemiology(3)

Publications15 total

PSMtags improve peptide sequencing and throughput in sensitive proteomics
2025· 4 citedOpen Access
SARS-CoV-2 3CLpro Main Protease Drives Cytoskeletal Reorganization and Tunnelling Nanotube Formation for Stealth Intercellular Infection
Research Square (Research Square)·2024Open Access
Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir
Organic Letters·2023· 6 cited
Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition
Frontiers in Chemistry·2022· 41 citedOpen Access
Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS-CoV-2 M<sup>pro</sup>
The Journal of Organic Chemistry·2021· 11 citedOpen Access
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability
Journal of Medicinal Chemistry·2021· 103 citedOpen Access
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
European Journal of Medicinal Chemistry·2021· 94 citedOpen Access
N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer
Journal of Molecular Biology·2021· 45 citedOpen Access
N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 M <sup>pro</sup>
2021· 2 cited
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors
RSC Medicinal Chemistry·2021· 59 citedOpen Access
Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Nature Communications·2020· 18 citedOpen Access
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Nature Communications·2020· 456 citedOpen Access
Structural insights into the feline coronavirus drug GC376, which inhibits the main protease of SARS-CoV-2 and blocks virus replication
Acta Crystallographica Section A Foundations and Advances·2020
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
2020· 76 citedOpen Access
Synthesis of Chiral Spin-Labeled Amino Acids
Organic Letters·2019· 10 cited

Frequent Co-authors

John C. Vederas(14), Tess Lamer(11), M. Joanne Lemieux(11), Muhammad Bashir Khan(10), Elena Arutyunova(10), Howard S. Young(10), Conrad Fischer(9), D. Lorne Tyrrell(9), Marco J. van Belkum(8), Justin Shields(7), Holly A. Saffran(7), Michael Joyce(7), Ryan T. McKay(6), Jimmy Lu(6), James A. Nieman(4), Alexandr Belovodskiy(3), Bing Bai(2), Mostofa Abu Hena(2), K. A. Srinivas(2), Sardeev K. Bajwa(1)