D. Lorne Tyrrell

University of North Carolina at Chapel Hill — United States

Medicine · Health Sciences

52h-index10.1kcitations273works2.02yr avg
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Research Topics

Hepatitis C virus research(95), Hepatitis B Virus Studies(78), HIV/AIDS drug development and treatment(33), SARS-CoV-2 and COVID-19 Research(29), Liver Disease Diagnosis and Treatment(24)

Publications273 total

Murine Models of Hepatitis A Virus Infection
UNC Libraries·2025Open Access
Phase I Trial of a Peptide-Based Vaccine to Prevent Group A Streptococcal Infection
2025Open Access
Human Antibodies to M-Protein Epitope-Based Vaccines Demonstrate Increased Immunogenicity and Streptococcus pyogenes (StrepA) Bactericidal Activity
2025Open Access
Angiostatin—a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology
Journal of Thrombosis and Haemostasis·2025
A quantitative, label-free visual interference colour assay platform for protein targeting and binding assays
npj Biosensing·2024Open Access
A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers
Trials·2024· 6 citedOpen Access
Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
ACS Medicinal Chemistry Letters·2024· 2 citedOpen Access
Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody–mediated tissue factor procoagulant activity in cultured endothelial cells
Journal of Thrombosis and Haemostasis·2024· 2 citedOpen Access
Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone
Journal of Hepatology·2024· 8 citedOpen Access
The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
ACS Bio & Med Chem Au·2023· 7 citedOpen Access
OC 22.5 Effect of Angiostatin and its Neutralization on Cellular Infection by SARS-CoV and SARS-CoV-2
Research and Practice in Thrombosis and Haemostasis·2023Open Access
Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles
Microbiology Spectrum·2023· 32 citedOpen Access
177 Single Cell Rna Sequencing Characterization of an in Vitro Model for Studies of Hepatitis B Virus
Radiotherapy and Oncology·2023
Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
Clinical Infectious Diseases·2023· 7 citedOpen Access
Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1
Journal of Interferon & Cytokine Research·2023· 7 cited
Bovine Serum Albumin-Protected Gold Nanoclusters for Sensing of SARS-CoV-2 Antibodies and Virus
ACS Applied Materials & Interfaces·2023· 12 cited
Utilization of a Glucometer Test Strip and Enzymatic Reactions to Quantify Anti-SARS-CoV-2 Spike RBD IgG Antibody and SARS-CoV-2 Virus in Saliva and Serum
Analytical Chemistry·2023· 11 cited
Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection
Frontiers in Immunology·2023· 17 citedOpen Access
Multiplex Assays Enable Simultaneous Detection and Identification of SARS-CoV-2 Variants of Concern in Clinical and Wastewater Samples
ACS Measurement Science Au·2023· 8 citedOpen Access
A171 INTESTINAL INTERFERON-LAMBDA RECEPTOR 1 EXPRESSION AND RESPONSES ARE SIGNIFICANTLY DECREASED IN PEDIATRIC INFLAMMATORY BOWEL DISEASE PATIENTS
Journal of the Canadian Association of Gastroenterology·2023· 1 citedOpen Access
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Frequent Co-authors

Michael Joyce(20), Michael Houghton(10), Justin Shields(9), Norman M. Kneteman(9), Deanna M. Santer(8), Holly A. Saffran(7), Elena Arutyunova(6), M. Joanne Lemieux(6), Wayne Vuong(5), Muhammad Bashir Khan(5), Tess Lamer(5), Howard S. Young(5), John C. Vederas(5), Karl P. Fischer(5), Conrad Fischer(4), Marco J. van Belkum(4), Graham Tipples(4), Wei Feng(4), Hanyong Peng(4), Hongquan Zhang(4)