Conrad Fischer

University of Alberta — Canada

Chemistry · Physical Sciences

20h-index1.7kcitations75works4.22yr avg
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Research Topics

Supramolecular Chemistry and Complexes(20), SARS-CoV-2 and COVID-19 Research(13), Crystallography and molecular interactions(12), Crystal structures of chemical compounds(8), Apelin-related biomedical research(8)

Publications75 total

Screening apelin analogues and a small molecule agonist as effective cardiovascular therapeutics against reperfusion injury
RSC Medicinal Chemistry·2025Open Access
Structural insights into the nirmatrelvir-resistant SARS-CoV-2 M<sup>pro</sup> L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design
RSC Medicinal Chemistry·2025Open Access
Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
ACS Medicinal Chemistry Letters·2024· 2 citedOpen Access
A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M<sup>pro</sup>) of SARS-CoV-2 and MERS-CoV
JACS Au·2024· 17 citedOpen Access
Assessment of optimized FRET substrates as universal corona- and picornavirus main protease substrates for screening assays
RSC Advances·2024· 2 citedOpen Access
SARS-CoV-2 Mpro Inhibitors: Achieved Diversity, Developing Resistance and Future Strategies
Future Pharmacology·2023· 29 citedOpen Access
Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition
Frontiers in Chemistry·2022· 41 citedOpen Access
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability
Journal of Medicinal Chemistry·2021· 103 citedOpen Access
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
European Journal of Medicinal Chemistry·2021· 94 citedOpen Access
N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer
Journal of Molecular Biology·2021· 45 citedOpen Access
Impaired performance of SARS-CoV-2 antigen-detecting rapid tests at elevated and low temperatures
2021
N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 M <sup>pro</sup>
2021· 2 cited
Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators
RSC Medicinal Chemistry·2021· 16 citedOpen Access
Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Nature Communications·2020· 18 citedOpen Access
Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity
Journal of Medicinal Chemistry·2020· 19 citedOpen Access
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Nature Communications·2020· 456 citedOpen Access
Structural insights into the feline coronavirus drug GC376, which inhibits the main protease of SARS-CoV-2 and blocks virus replication
Acta Crystallographica Section A Foundations and Advances·2020
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
2020· 76 citedOpen Access
A patent review of apelin receptor (APJR) modulators (2014-2019)
Expert Opinion on Therapeutic Patents·2020· 27 cited
Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury
Journal of Clinical Investigation·2019· 65 citedOpen Access
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Frequent Co-authors

Edwin Weber(22), John C. Vederas(20), Wilhelm Seichter(19), Tess Lamer(12), Marco J. van Belkum(11), M. Joanne Lemieux(10), Tobias Gruber(10), Elena Arutyunova(9), Howard S. Young(9), Wayne Vuong(8), Muhammad Bashir Khan(8), D. Lorne Tyrrell(8), Gavin Y. Oudit(7), Petra Bombicz(7), Justin Shields(6), Holly A. Saffran(6), Michael Joyce(6), Wang Wang(6), Ryan T. McKay(5), Jimmy Lu(5)