Sarah M. Heissler

The Ohio State University Wexner Medical Center — United States

Medicine · Health Sciences

25h-index2.0kcitations75works3.52yr avg
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Research Topics

Cardiomyopathy and Myosin Studies(45), Cellular Mechanics and Interactions(42), Muscle Physiology and Disorders(25), Hippo pathway signaling and YAP/TAZ(9), Ion channel regulation and function(5)

Publications75 total

MYH9 mutations differentially stabilize non-muscle myosin II filaments and induce distinct cellular aggregation phenotypes
Cellular and Molecular Life Sciences·2026Open Access
Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Nav1.5
Nature Communications·2026Open Access
Correction: Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation
The Journal of Cell Biology·2026Open Access
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation
The Journal of Cell Biology·2025Open Access
Structural basis of nonmuscle myosin-2 autoinhibition mechanisms
2025Open Access
Structural and Functional Mechanisms Underlying Activation Gate Dynamics and IFM Motif Accessibility in Human Na <sub>v</sub> 1.5
2025Open Access
Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific <i>MYH9</i> Mutations
2025· 2 citedOpen Access
Structural basis of human Na <sub>v</sub> 1.5 gating mechanisms
Proceedings of the National Academy of Sciences·2025· 6 citedOpen Access
BPS2025 - Structural basis of human Nav1.5 gating mechanisms
Biophysical Journal·2025
BPS2025 - Mechanisms of dysferlin-mediated membrane repair in health and disease
Biophysical Journal·2025
Cryo-EM structures of the membrane repair protein dysferlin
Nature Communications·2024· 8 citedOpen Access
Cryo-EM structures of cardiac muscle α-actin mutants M305L and A331P give insights into the structural mechanisms of hypertrophic cardiomyopathy
European Journal of Cell Biology·2024· 1 citedOpen Access
Structure, regulation, and mechanisms of nonmuscle myosin-2
Cellular and Molecular Life Sciences·2024· 11 citedOpen Access
Structural and functional mechanisms of actin isoforms
FEBS Journal·2024· 23 citedOpen Access
Structural basis of human Nav1.5 gating mechanisms
2024· 2 citedOpen Access
Competition between myosin II and βH-spectrin regulates cytoskeletal tension
eLife·2023· 3 citedOpen Access
Author Response: Competition between myosin II and βH-spectrin regulates cytoskeletal tension
2023Open Access
Competition between myosin II and βH-Spectrin regulates cytoskeletal tension
2023Open Access
Author Response: Competition between myosin II and βH-Spectrin regulates cytoskeletal tension
2023Open Access
Structural insights into actin isoforms
eLife·2023· 49 citedOpen Access
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Frequent Co-authors

James R. Sellers(26), Krishna Chinthalapudi(20), Dietmar J. Manstein(12), Neil Billington(7), Hsiang-Ling Huang(6), Matthias Preller(5), Yasuharu Takagi(4), Manuel H. Taft(4), Giovanna Grandinetti(4), Yi Yang(3), Amandeep Singh Arora(3), Andrejus Suchenko(3), Mohan K. Balasubramanian(3), Jordan R. Beach(2), Kirsten Remmert(2), Stephanie Guzik-Lendrum(2), John A. Hammer(2), Mirco Müller(2), Ralph P. Diensthuber(2), Igor Chizhov(2)