Dietmar J. Manstein

Medizinische Hochschule Hannover — Germany

Medicine · Health Sciences

54h-index9.1kcitations256works1.62yr avg
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Research Topics

Cardiomyopathy and Myosin Studies(109), Cellular Mechanics and Interactions(78), Muscle Physiology and Disorders(61), Force Microscopy Techniques and Applications(24), Cellular transport and secretion(15)

Publications253 total

Mechanics of blunting of actin–myosin interaction dynamics by the actinopathy‐causing mutation E334Q in cytoskeletal γ‐actin
The Journal of Physiology·2025· 1 citedOpen Access
Structure of the human nonmuscle myosin 2A motor domain: Insights into isoform-specific mechanochemistry
Journal of Biological Chemistry·2025Open Access
Disruption of <scp>SETD</scp> 3‐mediated histidine‐73 methylation by the <scp>BWCFF</scp> ‐associated β‐actin <scp>G</scp> 74 <scp>S</scp> mutation
FEBS Letters·2025· 2 citedOpen Access
Author response for "Disruption of SETD3-mediated histidine-73 methylation by the BWCFF-associated β-actin G74S mutation"
2025
Sarcomeric Remodelling in Human Heart Failure unraveled by single molecule long read sequencing
2025· 1 citedOpen Access
Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome
FEBS Journal·2025· 9 citedOpen Access
Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression
European Heart Journal·2025· 2 citedOpen Access
Abstract 4145767: Genetic impairment in myosin-5b related transport processes mediates cardiac dysfunction and sudden cardiac death
Circulation·2024
Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog TpmCdc8
Journal of Biological Chemistry·2024· 2 citedOpen Access
The Novel MYH9 Variant, c.1270C&gt;G, p.Arg424Gly, Causes Epstein-Fechtner Syndrome by the Modification of Nonmuscular Myosin IIA Contraction
Journal of the American Society of Nephrology·2024
Genomic and biological panoramas of non-muscle actinopathies
2024· 5 citedOpen Access
Motor properties of Myosin 5c are modulated by tropomyosin isoforms and inhibited by pentabromopseudilin
Frontiers in Physiology·2024· 4 citedOpen Access
Baraitser–Winter Syndrome Hotspot Mutation R196H in Cytoskeletal β–actin Reduces F–actin Stability and Perturbs Interaction with the Arp2/3 Complex
2024· 1 citedOpen Access
Biochemical characterization of cardiac α‐actin mutations <scp>A21V</scp> and <scp>D26N</scp> implicated in hypertrophic cardiomyopathy
Cytoskeleton·2024· 5 citedOpen Access
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
eLife·2024· 1 citedOpen Access
Author Response: The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
2024Open Access
The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ– actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
2024Open Access
Reviewer #1 (Public Review): The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ– actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
2024Open Access
Reviewer #2 (Public Review): The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ– actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
2024Open Access
Author Response: The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ– actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
2024Open Access
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Frequent Co-authors

Manuel H. Taft(8), Michael A. Geeves(7), Stefan Raunser(5), James A. Spudich(5), Sarah M. Heissler(5), Setsuko Fujita‐Becker(5), Roman Fedorov(5), Mirco Müller(4), Matthias Preller(4), Elmar Behrmann(3), Wolfgang A. Linke(3), Thomas F. Reubold(3), Susanne Eschenburg(3), Marcus Furch(3), Georgios Tsiavaliaris(3), Igor Chizhov(3), René Martin(3), Herwig O. Gutzeit(3), Hans‐Joachim Knölker(3), Julian von der Ecken(2)