Carolyn Biles

Medicine · Health Sciences

11h-index1.2kcitations16works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(10), HIV Research and Treatment(6), Chemical Synthesis and Analysis(4), Cancer therapeutics and mechanisms(3), HIV/AIDS Research and Interventions(2)

Publications16 total

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR of 3- and 4-Substituted Derivatives
Journal of Medicinal Chemistry·2000· 375 citedOpen Access
ChemInform Abstract: Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure‐Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogues.
ChemInform·1997· 3 cited
(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes
Journal of Virology·1996· 37 citedOpen Access
Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors:  Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs
Journal of Medicinal Chemistry·1996· 31 citedOpen Access
Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors
Journal of Medicinal Chemistry·1996· 86 citedOpen Access
Targeting Delavirdine/Atevirdine Resistant HIV-1:  Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors
Journal of Medicinal Chemistry·1996· 57 citedOpen Access
ChemInform Abstract: Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. Part 1. A Novel Class of Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors.
ChemInform·1994· 3 cited
Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Journal of Medicinal Chemistry·1994· 90 cited
Second generation bisheteroarylpiperazine (BHAP) HIV-1 reverse transcriptasae inhibitors: Enhancement of antiviral activity and aqueous solubility via 5- and 6-substitution of the indole ring
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·1993
ChemInform Abstract: A Novel Method for the tert‐Butylation of Aromatic Amines.
ChemInform·1993
A novel method for the t-butylation of aromatic amines
Tetrahedron Letters·1993· 5 cited
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)carbonyl]-4-[3-[(1-methylethyl)amino]pyridinyl]piperazinemonomethanesulfonate (U-90152S), a second-generation clinical candidate
Journal of Medicinal Chemistry·1993· 123 citedOpen Access
CC-1065(NSC 298223), a potent new antitumor agent. Improved production and isolation, characterization and antitumor activity.
The Journal of Antibiotics·1981· 140 citedOpen Access
Morphologic and histochemical analysis of hepatocytes transplanted into syngeneic hosts.
PubMed·1980· 75 citedOpen Access
Primary cultures of hepatocytes on human fibroblasts
In Vitro Cellular & Developmental Biology - Plant·1979· 119 cited
Structure of quinomycin antibiotics.
The Journal of Antibiotics·1975· 56 citedOpen Access

Frequent Co-authors

Donna L. Romero(10), Michaël Génin(6), Raymond A. Morge(6), Irene W. Althaus(5), Fritz Reusser(5), W. Gary Tarpley(4), Robert A. Olmsted(4), Toni J. Poel(4), Laurice A. Kopta(4), Richard Voorman(4), Yoshihiko Yagi(3), Richard C. Thomas(3), Paul D. Johnson(3), Barbara J. Keiser(3), Jan M. Friis(3), Wade J. Adams(3), Susan M. Poppe(2), David G. Martin(2), S. A. MIZSAK(2), JULIANNA C. STEWART(2)