Donna L. Romero

Medicine · Health Sciences

25h-index4.2kcitations65works1.72yr avg
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Research Topics

HIV/AIDS drug development and treatment(24), HIV Research and Treatment(16), Chemical Synthesis and Analysis(9), HIV/AIDS Research and Interventions(5), DNA and Nucleic Acid Chemistry(5)

Publications65 total

Therapeutic remodeling of the ceramide backbone prevents kidney injury
Cell Metabolism·2025· 1 citedOpen Access
Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes
Mobile DNA·2024· 4 citedOpen Access
WCN24-2618 ENCHANCEMENT OF MITOPHAGY VIA USP30 INHIBITION AS A THERAPEUTIC STRATEGY FOR ACUTE KIDNEY INJURY
Kidney International Reports·2024Open Access
Structures, functions and adaptations of the human LINE-1 ORF2 protein
Nature·2023· 109 citedOpen Access
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
Journal of Medicinal Chemistry·2023· 48 citedOpen Access
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Bioorganic & Medicinal Chemistry Letters·2022· 15 citedOpen Access
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition
Proceedings of the National Academy of Sciences·2022· 37 citedOpen Access
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
Journal of Medicinal Chemistry·2019· 73 citedOpen Access
Selective interleukin-1 receptor–associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy
The Journal of Experimental Medicine·2015· 155 citedOpen Access
Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field
Journal of the American Chemical Society·2015· 1.3k cited
Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders
Journal of Medicinal Chemistry·2014· 95 citedOpen Access
Abstract LB-112: Highly potent and selective interleukin-1 receptor-associated kinase 4 inhibitors for the therapy of lymphoid malignancies
Cancer Research·2014· 2 cited
Synergistic Blockade Of Activated B Cell-Like DLBCL Proliferation With a Selective Inhibitor Of IRAK4 In Combination With Inhibition Of The B-Cell Receptor Signaling Network
Blood·2013· 12 cited
Effect Of MYD88 Mutation In CLL On IRAK4 and BTK Inhibition In Vitro
Blood·2013· 3 cited
IRAK4 Kinase As A Novel Therapeutic Target in the ABC Subtype of Diffuse Large B Cell Lymphoma
Blood·2012· 20 cited
ChemInform Abstract: Bacterial Translation Inhibitors, 1‐Acylindazol‐3‐ols as Anthranilic Acid Mimics.
ChemInform·2009
Current HIV therapeutics: mechanistic and chemical determinants of toxicity.
PubMed·2009· 17 cited
CCDC 646069: Experimental Crystal Structure Determination
The Cambridge Structural Database·2009Open Access
CCDC 646068: Experimental Crystal Structure Determination
The Cambridge Structural Database·2009Open Access
Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis
Journal of Antimicrobial Chemotherapy·2008· 14 cited
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Frequent Co-authors

Carolyn Biles(9), Irene W. Althaus(9), W. Gary Tarpley(8), Fritz Reusser(8), Richard C. Thomas(8), Michaël Génin(7), Michael T. Sweeney(7), Keith R. Marotti(7), Shaughnessy Robinson(6), Paul A. Aristoff(6), Brian D. Wakefield(6), Gary E. Zurenko(6), Lionel Resnick(5), Martin R. Deibel(5), Ferenc J. Kézdy(5), Divya Chaudhary(5), Wenyan Miao(5), William Westlin(5), Raymond A. Morge(5), Robert A. Olmsted(5)