Sumei Ruan

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index852citations21works0.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(11), Hepatitis C virus research(8), Peptidase Inhibition and Analysis(8), HIV/AIDS drug development and treatment(6), Cell Adhesion Molecules Research(5)

Publications21 total

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor
ACS Medicinal Chemistry Letters·2010· 95 citedOpen Access
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 7 cited
Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P<sub>4</sub>-Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles
Journal of Medicinal Chemistry·2009· 26 cited
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034
Bioorganic & Medicinal Chemistry Letters·2008· 20 cited
Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
Journal of Medicinal Chemistry·2006· 278 citedOpen Access
Discovery of SCH446211 (SCH6):  A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication
Journal of Medicinal Chemistry·2006· 59 citedOpen Access
Depeptidization efforts on <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si2.gif" overflow="scroll"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">P</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub><mml:ms>–</mml:ms><mml:msubsup><mml:mrow><mml:mi mathvariant="normal">P</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math> α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
Bioorganic & Medicinal Chemistry Letters·2006· 18 citedOpen Access
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines
2005
Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
Holmes Museum Of Anthropology (Wichita State University)·2001
Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
Bioorganic & Medicinal Chemistry·2001· 33 cited
1,2,5-Thiadiazolidin-3-one 1,1 Dioxide: A Powerful Scaffold for Probing the S′ Subsites of (Chymo)trypsin-Like Serine Proteases
Archives of Biochemistry and Biophysics·2001· 21 cited
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates
Bioorganic & Medicinal Chemistry·2000· 51 cited
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates
Holmes Museum Of Anthropology (Wichita State University)·2000
A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold:  Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors
Journal of the American Chemical Society·1999· 55 cited
ChemInform Abstract: Use of the 1,2,5‐Thiadiazolidin‐3‐one 1,1 Dioxide and Isothiazolidin‐3‐one 1,1 Dioxide Scaffolds in the Design of Potent Inhibitors of Serine Proteinases.
ChemInform·1998
Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
Holmes Museum Of Anthropology (Wichita State University)·1998
Potent and Specific Inhibition of Human Leukocyte Elastase, Cathepsin G and Proteinase 3 by Sulfone Derivatives Employing the 1,2,5-Thiadiazolidin-3-one 1,1 Dioxide Scaffold
Bioorganic & Medicinal Chemistry·1998· 71 cited
Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases
Holmes Museum Of Anthropology (Wichita State University)·1998
Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases
Bioorganic & Medicinal Chemistry Letters·1998· 32 cited
Structure-Based Design of a General Class of Mechanism-Based Inhibitors of the Serine Proteinases Employing a Novel Amino Acid-Derived Heterocyclic Scaffold
Biochemistry·1997· 79 cited
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Frequent Co-authors

William C. Groutas(13), Rongze Kuang(12), R. Venkataraman(9), Stéphane Bogen(8), F. George Njoroge(8), Viyyoor Girijavallabhan(7), Jeffrey B. Epp(7), Weidong Pan(6), Shu He(6), Juan Tu(6), Ashok Arasappan(5), Andrew Prongay(5), Kuo-Chi Cheng(5), Anil K. Saksena(5), Tien M. Truong(5), Srikanth Venkatraman(4), Frank Bennett(4), Rong Liu(4), John Pichardo(4), Bahige M. Baroudy(4)