William C. Groutas

Wichita State University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index4.7kcitations230works3.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(56), Viral gastroenteritis research and epidemiology(38), Computational Drug Discovery Methods(30), Cell Adhesion Molecules Research(27), Peptidase Inhibition and Analysis(26)

Publications230 total

Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies
Journal of Medicinal Chemistry·2024· 2 citedOpen Access
Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus
Microbiology Spectrum·2024· 4 citedOpen Access
Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment
mBio·2023· 4 citedOpen Access
Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)
European Journal of Medicinal Chemistry·2023· 13 citedOpen Access
Carbocation Chemistry
2023
Questions 71-200
2023
Questions 35 - 50
2023
Lewis Structures
2023
Questions — 34
2023
Nucleophilic Acyl Substitution Reactions
2023
Answers to Questions 491-500
2023
Lewis acids and bases, and Lewis acid/Lewis base reactions
2023
Answers to Questions 35-50
2023
Chemical Reactivity and Ring Strain
2023
Answers to Questions 51-70
2023
Formation of Anions (Nucleophiles)
2023
Answers to Questions 201-490
2023
Nucleophilic Addition Reactions of Aldehydes and Ketones
2023
Organic Reaction Mechanisms, Selected Problems, and Solutions
2023· 3 cited
Resonance
2023
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Frequent Co-authors

Yunjeong Kim(24), Kyeong‐Ok Chang(17), Kevin R. Alliston(14), Scott Lovell(10), Sivakoteswara Rao Mandadapu(10), Anushka C. Galasiti Kankanamalage(10), Gerald H. Lushington(9), K.P. Battaile(8), Rongze Kuang(8), Kyeong-Ok Chang(7), Dengfeng Dou(7), R. Venkataraman(7), Athri D. Rathnayake(6), Pathum M. Weerawarna(6), Jeffrey B. Epp(6), Sumei Ruan(6), Sridhar Aravapalli(6), Duy H. Hua(5), Shu He(5), Juan Tu(5)