Kevin R. Alliston

Wichita State University — United States

Medicine · Health Sciences

22h-index1.5kcitations48works0.02yr avg
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Research Topics

Viral gastroenteritis research and epidemiology(19), Virus-based gene therapy research(11), Protease and Inhibitor Mechanisms(11), Viral Infections and Immunology Research(10), Animal Virus Infections Studies(4)

Publications48 total

Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease
Journal of Medicinal Chemistry·2017· 23 cited
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies
European Journal of Medicinal Chemistry·2016· 36 citedOpen Access
Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease
Journal of Medicinal Chemistry·2016· 28 citedOpen Access
1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (17-mer) inhibitor
2015
2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (21-mer) inhibitor
2015
Structure-Guided Design and Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Structure–Activity Relationships and Biochemical, X-ray Crystallographic, Cell-Based, and In Vivo Studies
Journal of Medicinal Chemistry·2015· 53 citedOpen Access
1.60 A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl inhibitor (1R,2S)-2-({N-[(benzyloxy)carbonyl]-3-cyclohexyl-L-alanyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (Hexagonal Form)
2014
1.85A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl inhibitor diethyl [(1R,2S)-2-[(N-{[(3-chlorobenzyl)oxy]carbonyl}-3-cyclohexyl-L-alanyl)amino]-1-hydroxy-3-(2-oxo-2H-pyrrol-3-yl)propyl]phosphonate
2014
Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 61 citedOpen Access
Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics
Bioorganic & Medicinal Chemistry Letters·2013· 25 citedOpen Access
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus
Bioorganic & Medicinal Chemistry Letters·2013· 46 citedOpen Access
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 47 citedOpen Access
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases
Bioorganic & Medicinal Chemistry·2012· 73 citedOpen Access
Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses
Journal of Virology·2012· 371 citedOpen Access
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
Bioorganic & Medicinal Chemistry Letters·2012· 60 citedOpen Access
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold
Bioorganic & Medicinal Chemistry·2012· 46 citedOpen Access
Potent norovirus inhibitors based on the acyclic sulfamide scaffold
Bioorganic & Medicinal Chemistry·2012· 21 cited
Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives
Bioorganic & Medicinal Chemistry·2011· 70 citedOpen Access
Cyclosulfamide-based derivatives as inhibitors of noroviruses
European Journal of Medicinal Chemistry·2011· 31 citedOpen Access
Potent inhibition of Norwalk virus by cyclic sulfamide derivatives
Bioorganic & Medicinal Chemistry·2011· 29 citedOpen Access
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Frequent Co-authors

William C. Groutas(42), Yunjeong Kim(17), Dengfeng Dou(14), Sivakoteswara Rao Mandadapu(13), Gerald H. Lushington(13), Kyeong‐Ok Chang(12), Xiangdong Gan(11), Jiaying Zhong(10), Zhong Lai(10), Pathum M. Weerawarna(9), Anushka C. Galasiti Kankanamalage(9), K.P. Battaile(8), Roxanne Adeline Z. Uy(7), Vishnu C. Damalanka(7), N. Mehzabeen(7), Christopher S. Groutas(7), Guijia He(6), Tzu‐Tshin Wong(6), Liuqing Wei(6), Sridhar Aravapalli(5)