Dengfeng Dou

University Health Network — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index910citations47works4.12yr avg
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Research Topics

Protease and Inhibitor Mechanisms(9), Computational Drug Discovery Methods(8), Chemical Synthesis and Analysis(7), Protein Degradation and Inhibitors(6), Viral gastroenteritis research and epidemiology(5)

Publications47 total

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV‑2
UNC Libraries·2026Open Access
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2
Journal of Chemical Information and Modeling·2026Open Access
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV‑2
Open MIND·2026
Deep seeking covalent DNA encoded library for novel JAK3 inhibitor discovery
Bioorganic & Medicinal Chemistry·2025
Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders
UNC Libraries·2025Open Access
Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Protein–ligand data at scale to support machine learning
Nature Reviews Chemistry·2025· 7 cited
TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms
Journal of Chemical Information and Modeling·2025· 2 cited
Chemically Induced Nuclear Pore Complex Protein Degradation via TRIM21
ACS Chemical Biology·2025· 15 cited
TRIM21-NUP98 Interface Accommodates Structurally Diverse Molecular Glue Degraders
ACS Chemical Biology·2025· 11 cited
Deep Seeking Covalent DNA Encoded Library for Novel Jak3 Inhibitor Discovery
SSRN Electronic Journal·2025Open Access
Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21
2024· 3 citedOpen Access
Enabling Open Machine Learning of DNA Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders
2024· 3 citedOpen Access
Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs
Journal of Medicinal Chemistry·2024· 6 citedOpen Access
The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening
Bioorganic & Medicinal Chemistry Letters·2024· 13 citedOpen Access
Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach
ACS Chemical Biology·2023· 51 citedOpen Access
Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA
Nucleic Acids Research·2022· 37 citedOpen Access
A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors
ACS Omega·2021· 36 citedOpen Access
Characterization of Specific <i>N</i> -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library
ACS Medicinal Chemistry Letters·2020· 34 citedOpen Access
Exploring the Lower Limit of Individual DNA-Encoded Library Molecules in Selection
SLAS DISCOVERY·2019· 29 citedOpen Access
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Frequent Co-authors

William C. Groutas(23), Kevin R. Alliston(14), Xue‐Min Cheng(10), Guijia He(9), Sivakoteswara Rao Mandadapu(7), Longying Cai(6), Yunjeong Kim(6), Kyeong‐Ok Chang(6), Sridhar Aravapalli(5), Gerald H. Lushington(5), David M. Eichhorn(5), Qiuxia Chen(5), Xian-Yang Li(5), Guansai Liu(5), Jin Li(5), Yi Li(5), A.M. Edwards(5), Kok-Chuan Tiew(4), Xiaoyun Meng(4), Shuai Xia(4)