Tomas Fex

Profu (Sweden) — Sweden

Chemistry · Physical Sciences

16h-index1.0kcitations45works0.02yr avg
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Research Topics

Analytical Chemistry and Chromatography(6), Chemical Synthesis and Analysis(6), Monoclonal and Polyclonal Antibodies Research(6), Protein purification and stability(6), Synthetic Organic Chemistry Methods(5)

Publications45 total

Novel histone deacetylase inhibitor, CS014, attenuates in vivo thrombosis while maintaining hemostasis
Journal of Thrombosis and Haemostasis·2025Open Access
Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function
Journal of Biological Chemistry·2020· 13 citedOpen Access
Plasminogen binding inhibitors demonstrate unwanted activities on GABA A and glycine receptors in human iPSC derived neurons
Neuroscience Letters·2018· 1 citedOpen Access
Comparison of weak affinity chromatography and surface plasmon resonance in determining affinity of small molecules
Analytical Biochemistry·2014· 16 cited
New Hits as Antagonists of GPR103 Identified by HTS
ACS Medicinal Chemistry Letters·2014· 6 citedOpen Access
Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein–Protein Interaction
ACS Medicinal Chemistry Letters·2014· 37 citedOpen Access
A serendipitously identified novel small molecule procoagulant compound giving rise to a high-throughput screening assay based on human plasma
Thrombosis Research·2013· 2 cited
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
2013
Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery
SLAS DISCOVERY·2013· 8 citedOpen Access
Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5
Bioorganic & Medicinal Chemistry Letters·2012· 30 citedOpen Access
High-Throughput Fragment Screening by Affinity LC-MS
SLAS DISCOVERY·2012· 35 citedOpen Access
3-Aminopiperidine-Based Peptide Analogues as the First Selective Noncovalent Inhibitors of the Bacterial Cysteine Protease IdeS
Journal of Medicinal Chemistry·2012· 14 citedOpen Access
Methods using weak interaction chromatography to separate and determine affinities of stereoisomers
2012
Weak affinity chromatography as a new approach for fragment screening in drug discovery
Analytical Biochemistry·2011· 74 cited
Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa
Bioorganic & Medicinal Chemistry Letters·2010· 23 citedOpen Access
Toward high‐throughput drug screening on a chip‐based parallel affinity separation platform
Journal of Separation Science·2010· 7 cited
Compounds Binding to the S2−S3 Pockets of Thrombin
Journal of Medicinal Chemistry·2009· 32 citedOpen Access
Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant
Bioorganic & Medicinal Chemistry·2009· 9 cited
Clavatadine A, A Natural Product with Selective Recognition and Irreversible Inhibition of Factor XIa
Journal of Medicinal Chemistry·2008· 79 citedOpen Access
Label-Free Primary Screening and Affinity Ranking of Fragment Libraries Using Parallel Analysis of Protein Panels
SLAS DISCOVERY·2008· 47 citedOpen Access
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Frequent Co-authors

Jan Kihlberg(10), Roland Isaksson(8), Sten Ohlson(8), Minh‐Dao Duong‐Thi(6), Maria Bergström(5), Fredrik Almqvist(4), Yafeng Xue(4), Anette Svensson(4), Jonas Boström(4), David Gustafsson(4), Börje Wickberg(4), Hans Emtenäs(3), Scott J. Hultgren(3), Jerome S. Pinkner(3), Emma Evertsson(3), Anders Thelin(3), Wolfgang Knecht(3), Ola Fjellström(3), Gunnar Andersson(2), Anette Svensson(2)