Abraham Nudelman

Bar-Ilan University — Israel

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index11.7kcitations202works0.32yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(30), Cancer therapeutics and mechanisms(16), Synthesis and Biological Evaluation(15), Carbohydrate Chemistry and Synthesis(13), Click Chemistry and Applications(13)

Publications202 total

Hybrids/Conjugates/Chimera Drugs-Antimicrobial Hybrids:Antibiotics, Antifungals, Antituberculars, Antimalarials
Current Medicinal Chemistry·2025
A Novel Oral Prodrug AN233 Induces Fetal Hemoglobin Expression in Sickle Cell Disease Mice and Baboons
Blood·2024
Hybrid/Chimera Drugs - Part 1 - Drug Hybrids Affecting Diseases of the Central Nervous System
Current Medicinal Chemistry·2024· 1 cited
Mutual Prodrugs - Codrugs
Current Medicinal Chemistry·2022· 13 cited
Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote
Scientific Reports·2022· 2 citedOpen Access
An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells
Cancer Chemotherapy and Pharmacology·2022· 2 cited
Valproic Acid Prodrug Affects Selective Markers, Augments Doxorubicin Anticancer Activity and Attenuates Its Toxicity in a Murine Model of Aggressive Breast Cancer
Pharmaceuticals·2021· 2 citedOpen Access
Dimeric Drugs
Current Medicinal Chemistry·2021· 10 cited
Comparison of the tissue distribution and metabolism of AN1284, a potent anti-inflammatory agent, after subcutaneous and oral administration in mice
Naunyn-Schmiedeberg s Archives of Pharmacology·2021· 1 cited
Abstract 992: A switch in mechanism of action attenuates doxorubicin-mediated cardiotoxicity
Cancer Research·2021
Dining with great chemists
2021Open Access
A switch in mechanism of action prevents doxorubicin-mediated cardiac damage
Biochemical Pharmacology·2021· 11 cited
A switch in mechanism of action attenuates doxorubicin-mediated cardiotoxicity.
Cancer Research·2021
Cardioprotection by AN-7, a prodrug of the histone deacetylase inhibitor butyric acid: Selective activity in hypoxic cardiomyocytes and cardiofibroblasts
European Journal of Pharmacology·2020· 9 cited
Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice
Blood Cells Molecules and Diseases·2019· 11 cited
Synthesis and Biological Evaluation of Derivatives of Indoline as Highly Potent Antioxidant and Anti-inflammatory Agents
Journal of Medicinal Chemistry·2018· 58 cited
Comparison of the anticancer properties of a novel valproic acid prodrug to leading histone deacetylase inhibitors
Journal of Cellular Biochemistry·2017· 16 cited
AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair
Investigational New Drugs·2017· 17 cited
Effect of Histone Deacetylase Inhibitor, Butyroyloxymethyl-Diethyl Phosphate (AN-7), on Corneal Neovascularization in a Mouse Model
Journal of Ocular Pharmacology and Therapeutics·2017· 8 cited
Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft
Investigational New Drugs·2017· 11 cited
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Frequent Co-authors

Ada Rephaeli(29), Don R. Phillips(12), Suzanne M. Cutts(12), Hugo E. Gottlieb(10), Nataly Tarasenko(6), Lonnie P. Swift(5), Michal Entin‐Meer(5), Eliezer Falb(4), J. Herzig(4), Zvi Malik(4), Ehud Keinan(3), Ester Rabizadeh(3), Mati Shaklai(3), Alfred Häßner(3), Yosi Bechor(2), Bilha Fischer(2), Margaretta Ruse(2), Adina Aviram(2), Yael Zimrah(2), Xiaodong Yang(2)