Nichole Helton

Washington University in St. Louis — United States

Medicine · Health Sciences

15h-index1.2kcitations69works1.22yr avg
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Research Topics

Acute Myeloid Leukemia Research(56), Epigenetics and DNA Methylation(17), Cancer Genomics and Diagnostics(13), Protein Degradation and Inhibitors(11), Retinoids in leukemia and cellular processes(6)

Publications69 total

Synthetic lethality of decitabine plus ATR inhibition for TP53-mutated AML
Blood Advances·2026Open Access
Mechanisms of chemotherapy resistance driven by Mecom overexpression
Blood·2025Open Access
Persistent binding of DNMT1 to chromatin causes replication dysfunction in TP53-mutated myeloid neoplasms
Blood·2025Open Access
The recurrent AML-associated CBFBD87GDSY mutation has hypomorphic function and is mechanistically distinct from CBFB:MYH11
Blood·2025Open Access
Heterogeneity of immune escape mechanisms in de novo Acute Myeloid Leukemia
Blood·2025Open Access
Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression
Journal of Clinical Investigation·2025· 2 citedOpen Access
VISTA As a Mediator of Immune Suppression in AML Initiated By <i>DNMT3A</i> and <i>NPM1</i> mutations
Blood·2024
Recurrent Amplification of Chromosome 7 in Murine AML with <i>Dnmt3a</i>R878H and <i>Npm1</i>cA Mutations Identifies <i>Gab2</i> As a Possible Therapeutic Target in AML
Blood·2024Open Access
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells
Proceedings of the National Academy of Sciences·2024· 4 citedOpen Access
Rapid and accurate remethylation of DNA in <i>Dnmt3a-</i> deficient hematopoietic cells with restoration of DNMT3A activity
Science Advances·2024· 6 citedOpen Access
Mechanisms of PML::Rara and GATA2 Protein Interactions in Hematopoietic Cells
Blood·2023Open Access
Overexpression of the Signaling Integrator <i>Gab2</i> Accelerates AML Development in Mice with <i>Dnmt3a R878H</i>and <i>Npm1 cA</i> Mutations
Blood·2023Open Access
Rapid and Accurate Remethylation of <i>Dnmt3a</i> Deficient Hematopoietic Cells with Restoration of DNMT3A Activity
Blood·2023· 1 cited
Genomic landscape of <i>TP53</i>-mutated myeloid malignancies
Blood Advances·2023· 26 citedOpen Access
Supplementary Table from Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
2023Open Access
Supplementary Table from Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
2023Open Access
Supplementary Data from Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
2023Open Access
Supplementary Data from Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
2023Open Access
Supplementary Table from Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
2023Open Access
Supplementary Table from Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
2023Open Access
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Frequent Co-authors

Timothy J. Ley(46), Christopher A. Miller(41), Robert S. Fulton(29), Daniel C. Link(28), Sai Mukund Ramakrishnan(27), Sharon E. Heath(25), Catrina C. Fronick(24), Matthew J. Walter(23), Peter Westervelt(22), John F. DiPersio(22), Jacqueline E. Payton(19), Sridhar Nonavinkere Srivatsan(15), David H. Spencer(14), Allegra A. Petti(13), Ryan B. Day(10), Saad Khan(9), Ziheng Xu(9), John S. Welch(8), Jeffery M. Klco(7), Daniel R. George(7)