Christopher L. Nobles

Exact Sciences (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index5.9kcitations44works1.02yr avg
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Research Topics

CRISPR and Genetic Engineering(16), CAR-T cell therapy research(15), Immune Cell Function and Interaction(7), HIV Research and Treatment(6), Virus-based gene therapy research(5)

Publications44 total

Performance of a multi-target, multi-cancer early detection (MCED) blood test in a prospectively collected cohort
2025· 1 citedOpen Access
189P Design and enrollment for a classifier development study for a blood-based multi-cancer early detection (MCED) test
Annals of Oncology·2023· 3 citedOpen Access
Abstract IA023: Improved sensitivity of a multi-analyte early detection test based on mutation, methylation, aneuploidy, and protein biomarkers
Cancer Prevention Research·2023
Abstract P041: Improved sensitivity of a multi-analyte early detection test based on mutation, methylation, aneuploidy, and protein biomarkers
Cancer Prevention Research·2023· 4 cited
Author Correction: Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
Nature·2022· 6 citedOpen Access
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
Nature Medicine·2022· 456 citedOpen Access
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
Nature·2022· 853 citedOpen Access
Decade-Long Remissions of Leukemia Sustained By the Persistence of Activated CD4+ CAR T-Cells
Blood·2021· 3 cited
Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells
2021· 1 citedOpen Access
Decade-long remissions of leukemia sustained by the persistence of activated CD4 <sup>+</sup> CAR T-cells
2021· 2 citedOpen Access
A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020
Molecular Therapy — Nucleic Acids·2021· 36 citedOpen Access
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo
Journal of Clinical Investigation·2020· 159 citedOpen Access
Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4 <sup>+</sup> T cells <i>in vivo</i>
2020· 1 citedOpen Access
iGUIDE Method for CRISPR Off-Target Detection
Methods in molecular biology·2020· 4 cited
Assessment of HIV-1 integration in tissues and subsets across infection stages
JCI Insight·2020· 21 citedOpen Access
Clonal tracking in gene therapy patients reveals a diversity of human hematopoietic differentiation programs
Blood·2020· 69 citedOpen Access
CRISPR-engineered T cells in patients with refractory cancer
Science·2020· 1.4k citedOpen Access
CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration
Journal of Clinical Investigation·2019· 125 citedOpen Access
First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma
Blood·2019· 14 cited
Optimization of CRISPR-Cas9 knock-out of CD33 in human hematopoietic stem / progenitor cells for allogeneic transplantation in patients with acute myeloid leukemia
Cytotherapy·2019· 4 cited
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Frequent Co-authors

Frederic D. Bushman(29), Carl H. June(19), J. Joseph Melenhorst(18), Simon F. Lacey(15), Joseph A. Fraietta(14), Megan M. Davis(12), Irina Kulikovskaya(12), Bruce L. Levine(10), Regina M. Young(10), J.K. Everett(10), Yangbing Zhao(9), Saar Gill(9), David E Ambrose(9), Minnal Gupta(8), Lifeng Tian(8), January Salas-McKee(8), Anne Chew(8), Shantan Reddy(8), Donald L. Siegel(7), Noelle V. Frey(7)