Adriana Marcelo

Algarve Biomedical Center — Portugal

Neuroscience · Life Sciences

9h-index532citations16works0.02yr avg
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Research Topics

Genetic Neurodegenerative Diseases(11), Mitochondrial Function and Pathology(5), Muscle Physiology and Disorders(4), Autophagy in Disease and Therapy(3), RNA Research and Splicing(3)

Publications16 total

Molecular hallmarks of neurodegeneration in polyglutamine spinocerebellar ataxias
Cell Death and Disease·2025Open Access
The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits
Brain·2022· 27 citedOpen Access
The stress granule protein G3BP1 reduces the levels of polyglutamine proteins and alleviates spinocerebellar ataxia associated deficits
2022Open Access
Autophagy is dysregulated in spinocerebellar ataxia type 2
Autophagy Reports·2022Open Access
Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy
Cell Death and Disease·2021· 36 citedOpen Access
The stress granule protein G3BP1 reduces the levels of different polyglutamine proteins and alleviates spinocerebellar ataxia associated deficits
2021Open Access
Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?
Cell Death and Disease·2021· 208 citedOpen Access
STUDY OF AUTOPHAGY IN SPINOCEREBELLAR ATAXIA TYPE 2MODELS: FROM DYSFUNCTION TO A THERAPEUTIC APPROACH
2021
Mesenchymal Stromal Cells’ Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?
Frontiers in Cellular Neuroscience·2020· 8 citedOpen Access
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease
BMC Research Notes·2020· 16 citedOpen Access
CYP46A1- gene therapy improves Machado-Joseph disease in mouse models
Sapientia (Algarve University)·2020Open Access
Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia
Acta Neuropathologica·2019· 73 citedOpen Access
MSGP: the first database of the protein components of the mammalian stress granules
Database·2019· 67 citedOpen Access
Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models
Human Molecular Genetics·2018· 39 cited
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease
Molecular Therapy·2018· 37 citedOpen Access
Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector
Materials Science and Engineering C·2015· 21 cited

Frequent Co-authors

Clévio Nóbrega(13), Carlos A. Matos(12), Luís Pereira de Almeida(10), Rebekah Koppenol(8), Liliana Mendonça(6), Sandra O. Tomé(5), André Conceição(5), Rafael G. Costa(4), Nathalie Cartier(3), Sandro Alves(3), Inês T. Afonso(3), Ricardo Afonso‐Reis(3), David V.C. Brito(3), Antonin Lamazière(2), Gaëtan Després(2), Fatich Mechmet(2), Dominique Langui(2), Wilfred F.A. den Dunnen(2), Sara Carmo‐Silva(2), João Alves-Cruzeiro(2)