Sandro Alves

North Carolina Biotechnology Center — United States

Neuroscience · Life Sciences

24h-index8.2kcitations49works2.82yr avg
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Research Topics

Genetic Neurodegenerative Diseases(19), Mitochondrial Function and Pathology(14), Alzheimer's disease research and treatments(10), Autophagy in Disease and Therapy(5), Virus-based gene therapy research(4)

Publications49 total

Role of visual and non-visual opsins in blue light–induced neurodegeneration in Drosophila melanogaster
Frontiers in Public Health·2025Open Access
Astrocyte-neuron combined targeting for CYP46A1 gene therapy in Huntington’s disease
Acta Neuropathologica Communications·2025· 2 citedOpen Access
Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model
Frontiers in Neuroscience·2025· 5 citedOpen Access
Modulation of Brain Cholesterol Metabolism through CYP46A1 Overexpression for Rett Syndrome
Pharmaceutics·2024· 4 citedOpen Access
Investigating the Effects of Brain Cholesterol Metabolism Using CYP46A1 Gene Therapy in Subjects with Huntington’s Disease (P1-11.016)
Neurology·2023· 2 cited
Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer's Disease Predementia
The Journal of Prevention of Alzheimer s Disease·2022· 9 citedOpen Access
The Challenge of Gene Therapy for Neurological Diseases: Strategies and Tools to Achieve Efficient Delivery to the Central Nervous System
Human Gene Therapy·2020· 40 citedOpen Access
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
UNC Libraries·2020· 3 citedOpen Access
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease
BMC Research Notes·2020· 16 citedOpen Access
CYP46A1- gene therapy improves Machado-Joseph disease in mouse models
Sapientia (Algarve University)·2020Open Access
Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain
Molecular Therapy — Methods & Clinical Development·2019· 45 citedOpen Access
Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia
Acta Neuropathologica·2019· 73 citedOpen Access
Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice
Acta Neuropathologica Communications·2019· 45 citedOpen Access
SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models
Disease Models & Mechanisms·2018· 24 citedOpen Access
O5‐06‐04: AAV‐CYP46A1 BRAIN DELIVERY MITIGATES ALZHEIMER'S DISEASE: FROM MOUSE MODELS TO NON‐HUMAN PRIMATES
Alzheimer s & Dementia·2018· 2 cited
Editorial: Gene Silencing and Editing Strategies for Neurodegenerative Diseases
Frontiers in Neuroscience·2018· 1 citedOpen Access
SCA3, Machado-Joseph Disease
Elsevier eBooks·2018
Deregulation of autophagy in postmortem brains of Machado‐Joseph disease patients
Neuropathology·2017· 62 citedOpen Access
Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future
Human Gene Therapy·2017· 104 cited
βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease
Cerebral Cortex·2017· 20 cited
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Frequent Co-authors

Nathalie Cartier(26), Jérôme Braudeau(10), Nicole Déglon(10), Martina Marinello(9), Alexis Brice(9), Annie Sittler(9), Philippe Hantraye(8), Mickaël Audrain(8), Romain Fol(8), Noëlle Dufour(7), Luís Pereira de Almeida(7), Françoise Piguet(7), Patrick Aubourg(6), Raymonde Hässig(6), Emmanuel Brouillet(6), Gaëtan Després(6), Wilfred F.A. den Dunnen(6), Gwennaëlle Aurégan(5), Isabel Nascimento-Ferreira(5), Antonin Lamazière(5)