Gwennaëlle Aurégan

Centre National de la Recherche Scientifique — France

Neuroscience · Life Sciences

18h-index2.6kcitations26works4.02yr avg
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Research Topics

Genetic Neurodegenerative Diseases(8), Alzheimer's disease research and treatments(5), Mitochondrial Function and Pathology(5), Neuroscience and Neuropharmacology Research(4), Nerve injury and regeneration(4)

Publications26 total

Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits
Brain·2025· 4 citedOpen Access
Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology
Neurobiology of Disease·2023· 4 citedOpen Access
Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway
Brain·2022· 63 citedOpen Access
THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency
Neurobiology of Disease·2021· 26 citedOpen Access
The Neuroprotective Agent CNTF Decreases Neuronal Metabolites in the Rat Striatum: An <i>in Vivo</i> Multimodal Magnetic Resonance Imaging Study
Journal of Cerebral Blood Flow & Metabolism·2015· 21 citedOpen Access
The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases
Journal of Neuroscience·2015· 305 citedOpen Access
Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
PLoS ONE·2014· 211 citedOpen Access
Allele-Specific Silencing of Mutant Huntingtin in Rodent Brain and Human Stem Cells
PLoS ONE·2014· 54 citedOpen Access
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
Acta Neuropathologica Communications·2014· 252 citedOpen Access
BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities
Translational Psychiatry·2013· 232 citedOpen Access
Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain
Molecular Therapy·2013· 36 citedOpen Access
A3-2 MicroRNAs detargeting technology in the context of CNS applications
2012
A3-2 MicroRNAs detargeting technology in the context of CNS applications
2012
Restricted transgene expression in the brain with cell-type specific neuronal promoters
Human Gene Therapy Methods·2012· 3 cited
Restricted Transgene Expression in the Brain with Cell-Type Specific Neuronal Promoters
Human Gene Therapy Methods·2012· 43 citedOpen Access
Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression
Journal of Neuroscience·2011· 96 citedOpen Access
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease
Brain·2011· 201 citedOpen Access
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects
Human Molecular Genetics·2010· 325 citedOpen Access
Silencing ataxin-3 mitigates degeneration in a rat model of Machado–Joseph disease: no role for wild-type ataxin-3?
Human Molecular Genetics·2010· 105 citedOpen Access
Doublecortin-like kinase 3 (DCLK3), a novel striatum-enriched species, is amodulator of mutant huntingtin in vivo
HAL (Le Centre pour la Communication Scientifique Directe)·2009
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Frequent Co-authors

Philippe Hantraye(19), Nicole Déglon(18), Noëlle Dufour(16), Emmanuel Brouillet(16), Gilles Bonvento(11), Martine Guillermier(8), Raymonde Hässig(8), Carole Escartin(6), Marie‐Claude Gaillard(6), Fanny Petit(5), Diane Houitte(5), Sandro Alves(5), Mathilde Faideau(4), Luc Buée(4), Alexis‐Pierre Bemelmans(4), Karine Cambon(4), Lucile Ben Haim(3), María-Angeles Carrillo-de Sauvage(3), Simon Dujardin(3), Raphaëlle Caillierez(3)