Mickaël Audrain

AC Immune (Switzerland) — Switzerland

Medicine · Health Sciences

19h-index1.8kcitations53works4.72yr avg
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Research Topics

Alzheimer's disease research and treatments(28), Neuroinflammation and Neurodegeneration Mechanisms(14), Monoclonal and Polyclonal Antibodies Research(4), Cholinesterase and Neurodegenerative Diseases(4), Dementia and Cognitive Impairment Research(3)

Publications53 total

A single dose of a vectorized mAb targeting TDP-43 potently inhibits the neuropathology in a model of ALS/FTD
Molecular Therapy·2025· 1 citedOpen Access
Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD
Acta Neuropathologica Communications·2024· 6 citedOpen Access
Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice
Frontiers in Aging Neuroscience·2024· 7 citedOpen Access
Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice
2023· 1 citedOpen Access
Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework
mAbs·2023· 8 citedOpen Access
Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy
Journal of Neuroscience·2023· 23 citedOpen Access
Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD
Neurobiology of Disease·2023· 31 citedOpen Access
Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF
Brain Communications·2023· 13 citedOpen Access
Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females
Cells·2022· 19 citedOpen Access
Sexually‐dimorphic effects of C3aR1 disruption in a mouse model of Alzheimer’s disease
Alzheimer s & Dementia·2022Open Access
Erratum to: Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats
The Journal of Prevention of Alzheimer s Disease·2022Open Access
Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
Molecular Neurodegeneration·2022· 142 citedOpen Access
Erratum to: Cerebral phospho-tau acts synergistically with soluble Aβ42 leading to Mild Cognitive Impairment in AAV-AD rats
The journal of nutrition health & aging·2022
Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats
The Journal of Prevention of Alzheimer s Disease·2022· 7 citedOpen Access
Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer's Disease Predementia
The Journal of Prevention of Alzheimer s Disease·2022· 9 citedOpen Access
Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice
Alzheimer s & Dementia·2020· 59 citedOpen Access
Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer’s-related mice
2020· 7 citedOpen Access
Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
Nature Communications·2020· 181 citedOpen Access
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease
Acta Neuropathologica·2020· 37 citedOpen Access
VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice
Molecular Neurodegeneration·2020· 104 citedOpen Access
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Frequent Co-authors

Nathalie Cartier(19), Jérôme Braudeau(19), Michelle E. Ehrlich(17), Sam Gandy(16), Eric E. Schadt(12), Romain Fol(12), Minghui Wang(11), Bin Zhang(11), Jean‐Vianney Haure‐Mirande(10), Alexis‐Pierre Bemelmans(9), Noam D. Beckmann(8), Stephen R. Salton(8), Benoît Souchet(8), Sandro Alves(7), Tomas Fanutza(6), Robert D. Blitzer(6), Martin Körte(6), Nicola Salvatore Orefice(6), Wei‐Jye Lin(5), Cheng Jiang(5)