Kam Y. J. Zhang

RIKEN Center for Biosystems Dynamics Research — Japan

Materials Science · Physical Sciences

46h-index11.9kcitations217works3.72yr avg
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Research Topics

Enzyme Structure and Function(47), Protein Structure and Dynamics(44), Computational Drug Discovery Methods(41), RNA and protein synthesis mechanisms(23), Glycosylation and Glycoproteins Research(16)

Publications216 total

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein
UNC Libraries·2025Open Access
The Ser7 phosphorylation of RNA polymerase II-CTD is required for the recruitment of E3 ubiquitin ligase Asr1 and subtelomeric gene silencing
Journal of Biological Chemistry·2025Open Access
Identification of substituted acetanilide compounds as small molecule CBX2 inhibitors via in silico screening
Biochemical and Biophysical Research Communications·2025· 1 citedOpen Access
Expression, Purification, and Preliminary Characterization of Putative Protein Tyrosine Phosphatase Oca1
Protein and Peptide Letters·2025
Identification of benzimidazole-6-carboxamide based inhibitors of secretory glutaminyl cyclase for the treatment of Alzheimer's disease
International Journal of Biological Macromolecules·2024· 1 cited
Discovery of a Compound That Inhibits IRE1α <i>S</i>-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress
ACS Chemical Biology·2024· 2 citedOpen Access
CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein
Journal of Chemical Information and Modeling·2024· 23 citedOpen Access
Identification of substituted acetanilide compounds as small molecule CBX2 inhibitors via in silico screening
2024Open Access
CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson’s Disease associated protein
2024· 5 citedOpen Access
RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state
Journal of Biological Chemistry·2024· 5 citedOpen Access
The Ser7 of RNA Pol II-CTD influences the recruitment of Cdc73 for mRNA transcription
International Journal of Biological Macromolecules·2023· 2 cited
The Saccharomyces cerevisiae SR protein Npl3 interacts with hyperphosphorylated CTD of RNA Polymerase II
International Journal of Biological Macromolecules·2023· 5 cited
A community effort in SARS‐CoV‐2 drug discovery
Molecular Informatics·2023· 17 citedOpen Access
Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function
Frontiers in Immunology·2023· 6 citedOpen Access
A community effort to discover small molecule SARS-CoV-2 inhibitors
2023· 1 citedOpen Access
Supplementary Tables S1-S2 and Figures S1-S15 from The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide
2023Open Access
Supplementary Methods from EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
2023Open Access
Data from EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
2023Open Access
Supplementary methods from The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide
2023Open Access
Supplementary Methods from EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
2023Open Access
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Frequent Co-authors

Gideon Bollag(9), Ashutosh Kumar(8), Prabha N. Ibrahim(7), Jason O’Neill(7), Brian L. West(6), Dean R. Artis(6), Hoa Nguyen(5), Joseph Schlessinger(5), S. Gillette(5), Daniel W. Fong(5), David Baker(5), Chao Zhang(4), Gaston Habets(4), Ben Powell(4), Adhirai Marimuthu(4), Yoshihisa Suzuki(4), Sung‐Hou Kim(4), Kristine M. Kim(4), Arnout Voet(4), David E. Kim(4)