Zhuoyao Chen

Nuffield Orthopaedic Centre — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index593citations34works3.72yr avg
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Research Topics

Ubiquitin and proteasome pathways(11), Protein Degradation and Inhibitors(6), Microtubule and mitosis dynamics(4), Cancer-related Molecular Pathways(4), Polysaccharides and Plant Cell Walls(4)

Publications34 total

Fragment‐Based Drug Discovery of Novel High‐affinity, Selective, and Anti‐inflammatory Inhibitors of the Keap1‐Nrf2 Protein‐Protein Interaction
Angewandte Chemie International Edition·2025· 1 citedOpen Access
Fragment‐Based Drug Discovery of Novel High‐affinity, Selective, and Anti‐inflammatory Inhibitors of the Keap1‐Nrf2 Protein‐Protein Interaction
Angewandte Chemie·2025Open Access
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment
Nature Communications·2025· 3 citedOpen Access
Loss of IVNS1ABP, a gigaxonin paralogue, leads to a progeroid neuropathy due to impaired proteostasis
2024· 1 citedOpen Access
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment
2024Open Access
Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes
Nature Communications·2024· 17 citedOpen Access
HLA Alleles, COVID-19 Vaccine Antibody Response and Real-World Breakthrough Outcomes
Research Square (Research Square)·2023· 1 citedOpen Access
MEDB-62. Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
Neuro-Oncology·2022· 1 citedOpen Access
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
Cell Death and Differentiation·2022· 41 citedOpen Access
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase
Biochemical Journal·2022· 4 citedOpen Access
Ubiquitin ligases: guardians of mammalian development
Nature Reviews Molecular Cell Biology·2022· 201 cited
The role of E3 ubiquitin ligases in the development and progression of glioblastoma
Cell Death and Differentiation·2021· 82 citedOpen Access
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase
2020Open Access
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
Open Biology·2020· 17 citedOpen Access
Author response for "Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12"
2020
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
2020· 2 citedOpen Access
Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase
Structure·2019· 36 citedOpen Access
Human Kelch-like Protein 20 (KLHL20); A Target Enabling Package
Zenodo (CERN European Organization for Nuclear Research)·2019Open Access
Human Kelch-like ECH Associated Protein 1 (KEAP1); A Target Enabling Package
Figshare·2019Open Access
Human Kelch-like ECH Associated Protein 1 (KEAP1); A Target Enabling Package
Zenodo (CERN European Organization for Nuclear Research)·2019· 2 citedOpen Access
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Frequent Co-authors

Alex N. Bullock(28), Vincenzo D’Angiolella(15), F.J. Sorrell(11), S. Picaud(9), P. Filippakopoulos(9), Sergio G. Bartual(9), Jinwei Zhang(8), Dario R. Alessi(8), Daniel M. Pinkas(6), Joshua C. Bufton(6), Gerrit M. Daubner(6), Frances‐Rose Schumacher(6), George P. Georghiou(6), Thimo Kurz(6), Steven C. Clifford(4), Xiangrong Chen(4), Tryfon Zarganes‐Tzitzikas(4), James M. Bennett(4), Thomas Christott(4), Paul E. Brennan(4)