Joan Heller Brown

Lancaster General Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

94h-index26.2kcitations348works2.72yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(88), Cardiac electrophysiology and arrhythmias(75), Receptor Mechanisms and Signaling(73), Ion channel regulation and function(68), Mitochondrial Function and Pathology(35)

Publications348 total

Cardiomyocyte YAP represses myocardial inflammation and fibrosis and restrains MEF2-regulated gene expression
American Journal of Physiology-Heart and Circulatory Physiology·2025· 4 citedOpen Access
Readmission and Mortality in Trauma Patients Utilizing LACE Index
The American Surgeon·2025
Abstract Mo137: Modulation of the Inflammatory and Fibrotic Effects of Angiotensin on Cardiomyocytes through YAP-mediated Transcription.
Circulation Research·2024
Diuretics
2024
Ca2+/Calmodulin-Dependent Kinase IIδC-Induced Chronic Heart Failure Does Not Depend on Sarcoplasmic Reticulum Ca2+ Leak
ESC Heart Failure·2024· 9 citedOpen Access
Rib Fractures and Frailty in Geriatric Trauma Patients
The American Surgeon·2024· 3 cited
Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion
Scientific Reports·2023· 6 citedOpen Access
Nitric Oxide Modulates Ca <sup>2+</sup> Leak and Arrhythmias via S-Nitrosylation of CaMKII
Circulation Research·2023· 17 citedOpen Access
Nitric Oxide modulates spontaneous Ca <sup>2+</sup> release and ventricular arrhythmias during β-adrenergic signalling through <i>S</i> -nitrosylation of Calcium/Calmodulin dependent kinase II
2023Open Access
Effects of Chronic Box Mod E-cigarette Aerosol Exposures on Organ Damage and Gene Expression in Mice
2023
A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling
Scientific Reports·2023· 5 citedOpen Access
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria
Cell Death and Differentiation·2022· 48 citedOpen Access
Regulation of Glioblastoma Stem Cell Properties and Tumor Invasion by G <sub>⍺12</sub> Signaling
The FASEB Journal·2022
Author response: Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice
2022Open Access
Co‐occurrence of <i>BAP1</i> and <i>SF3B1</i> mutations in uveal melanoma induces cellular senescence
Molecular Oncology·2021· 25 citedOpen Access
Author response for "Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence"
2021
Author response for "Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence"
2021· 1 cited
CCL2‐ Dependent Macrophage Recruitment by Glioblastoma Stem Cells: The Role of Gα12 and YAP Signaling
The FASEB Journal·2021· 1 cited
Multi-Organ Inflammatory Effects by the Chronic Use of the Pod-Based Electronic Cigarette JUUL <sup>TM</sup> in Mice
2021
Cardiomyocyte NLRP3 Contributes to the Cardiac Inflammatory Response
The FASEB Journal·2021
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Frequent Co-authors

Kenneth R. Chien(11), Valerie P. Sah(9), Donald M. Bers(7), Lars S. Maier(5), Shigeki Miyamoto(5), Yibin Wang(4), John Ross(4), Kirk U. Knowlton(4), Tong Zhang(4), Tammy M. Seasholtz(4), Tong Zhang(4), Isao Ishii(4), Shuji Kawamura(4), Jerold Chun(4), Nancy D. Dalton(3), Nataliya Dybkova(3), Gerald W. Dorn(3), Masahiko Hoshijima(3), Yusu Gu(3), James J. A. Contos(3)