Spencer E. Brightman

Boston Children's Hospital — United States

Immunology and Microbiology · Life Sciences

13h-index573citations27works5.72yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Immunotherapy and Immune Responses(16), CAR-T cell therapy research(11), Cancer Immunotherapy and Biomarkers(9), Immune Response and Inflammation(7), Influenza Virus Research Studies(5)

Publications27 total

Discovery of a small molecule TLR3 agonist adjuvant
Nature Communications·2025Open Access
Advances in the development of personalized neoantigen therapies
The Journal of Experimental Medicine·2025
The spontaneous neoantigen-specific CD4 <sup>+</sup> T-cell response to a growing tumor is functionally and phenotypically diverse
Journal for ImmunoTherapy of Cancer·2025· 2 citedOpen Access
The spontaneous neoantigen-specific CD4 <sup>+</sup> T cell response to a growing tumor is functionally and phenotypically diverse
2025· 1 citedOpen Access
From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation
Science Advances·2024· 13 citedOpen Access
A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer
Science Translational Medicine·2024· 18 cited
Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
Journal of Clinical Investigation·2023· 56 citedOpen Access
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
Nature Immunology·2023Open Access
Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
Nature Immunology·2023· 69 citedOpen Access
Linked CD4 <sup>+</sup> /CD8 <sup>+</sup> T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
2023· 2 citedOpen Access
Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells
JCI Insight·2022· 15 citedOpen Access
Abstract C021: Targeted delivery of neoantigens to pancreatic cancer to enable immunotherapy
Cancer Research·2022
Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination
Scientific Reports·2022· 21 citedOpen Access
Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination
2022· 1 citedOpen Access
TCR-engineered neoantigen-specific CD4+ T cells mediate immunotherapy of a class II-negative murine squamous cell carcinoma
The Journal of Immunology·2022
Precision immunology for discovery and development of the <i>Precision Vaccines Program</i> (PVP)-037 small molecule series: imidazopyrimidine adjuvants identified via age-specific human <i>in vitro</i> modeling
The Journal of Immunology·2020· 1 cited
Harnessing neoantigen specific CD4 T cells for cancer immunotherapy
Journal of Leukocyte Biology·2020· 59 citedOpen Access
Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
Vaccine·2018· 19 citedOpen Access
Age-specific TLR7/8 adjuvant formulation overcomes hyporesponsiveness to neonatal acellular pertussis vaccination in a mouse model
The Journal of Immunology·2018· 1 cited
Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization
Frontiers in Immunology·2017· 46 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Ofer Levy(14), David J. Dowling(11), Stephen P. Schoenberger(11), Martin S. Naradikian(8), Ezra E.W. Cohen(8), Bjoern Peters(8), Rukman R. Thota(7), Francesco Borriello(7), Ilana Bergelson(6), Ashmitaa Logandha Ramamoorthy Premlal(6), Aaron M. Miller(6), Ryan Q. Griswold(5), Joseph S. Dolina(5), Wing Ki Cheng(5), Al Ozonoff(5), Simon D. van Haren(4), Angelica Becker(4), Jason Greenbaum(4), David J. Burkhart(4), Matthew A. Pettengill(4)