Jessica J. Pfannenstiel

University of Kansas — United States

Medicine · Health Sciences

8h-index245citations17works8.82yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(15), PARP inhibition in cancer therapy(6), Animal Virus Infections Studies(5), interferon and immune responses(5), Viral gastroenteritis research and epidemiology(4)

Publications17 total

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response
2025Open Access
IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice
PLoS ONE·2025Open Access
Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication
mBio·2025· 4 citedOpen Access
IFN- <i>γ</i> signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice
2025Open Access
Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication
2024· 1 citedOpen Access
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication
Journal of Virology·2024· 8 citedOpen Access
Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target
Journal of Medicinal Chemistry·2024· 17 citedOpen Access
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling
Proceedings of the National Academy of Sciences·2024· 41 citedOpen Access
Mutation of a highly conserved isoleucine residue in loop 2 of several 𝛽-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection
2024· 8 citedOpen Access
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling
2023· 12 citedOpen Access
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner
Journal of Virology·2023· 22 citedOpen Access
Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target
2023· 5 citedOpen Access
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice
Proceedings of the National Academy of Sciences·2023· 58 citedOpen Access
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice
2023· 11 citedOpen Access
Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles
Microbiology Spectrum·2022· 6 citedOpen Access
MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells
Proceedings of the National Academy of Sciences·2022· 51 citedOpen Access
MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells
2021· 1 citedOpen Access

Frequent Co-authors

Anthony R. Fehr(17), Catherine M. Kerr(7), Joseph J. O’Connor(7), Sunil More(5), Susan R. Weiss(5), Srivatsan Parthasarathy(5), Yousef M. Alhammad(4), Roshan Ghimire(4), Rudragouda Channappanavar(4), Clayton J. Otter(4), Li Tan(4), Noam A. Cohen(4), Men Thi Hoai Duong(4), Daniel Cluff(4), Dana Ferraris(4), L. Lehtiö(4), Pradtahna Saenjamsai(4), David K. Johnson(4), Anuradha Roy(4), David M. Renner(3)