Joseph J. O’Connor

University of Kansas — United States

Medicine · Health Sciences

7h-index176citations13works3.42yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(11), PARP inhibition in cancer therapy(7), COVID-19 Clinical Research Studies(3), Advancements in Semiconductor Devices and Circuit Design(3), Animal Virus Infections Studies(3)

Publications13 total

Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle
Journal of Virology·2025· 1 citedOpen Access
IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice
PLoS ONE·2025Open Access
IFN- <i>γ</i> signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice
2025Open Access
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication
Journal of Virology·2024· 8 citedOpen Access
Mutation of a highly conserved isoleucine residue in loop 2 of several 𝛽-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection
2024· 8 citedOpen Access
An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors
Pathogens·2023· 16 citedOpen Access
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner
Journal of Virology·2023· 22 citedOpen Access
Two Commercially Available Blood-Stabilization Reagents Serve as Potent Inactivators of Coronaviruses
Pathogens·2023· 1 citedOpen Access
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice
Proceedings of the National Academy of Sciences·2023· 58 citedOpen Access
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner
2023· 2 citedOpen Access
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice
2023· 11 citedOpen Access
Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication
Journal of Virology·2021· 48 citedOpen Access
An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication
2021· 1 citedOpen Access

Frequent Co-authors

Anthony R. Fehr(13), Catherine M. Kerr(10), Jessica J. Pfannenstiel(7), Sunil More(6), Yousef M. Alhammad(5), Nancy Schwarting(5), Roshan Ghimire(4), Rudragouda Channappanavar(4), David K. Johnson(4), Srivatsan Parthasarathy(4), Robin C. Orozco(4), Srivatsan Parthasarathy(3), Lynden S. Voth(3), Reem Khattabi(3), Philip Gao(3), Anuradha Roy(3), Debarati Chanda(2), Caden A. Miller(2), Robert L. Unckless(2), Sonia Zúñiga(2)