Eric J. Downer

Trinity College Dublin — Ireland

Medicine · Health Sciences

28h-index2.3kcitations71works3.62yr avg
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Research Topics

Cannabis and Cannabinoid Research(29), Neuroinflammation and Neurodegeneration Mechanisms(17), Immune Response and Inflammation(12), Neuroscience and Neuropharmacology Research(9), Sleep and Wakefulness Research(9)

Publications71 total

Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter and immune cells in multiple sclerosis
Multiple Sclerosis and Related Disorders·2026Open Access
A 1:1 combination of cannabidiol and Δ9-tetrahydrocannabinol inhibit toll-like receptor 7- and 8-mediated inflammation in human immune cells
European Journal of Pharmacology·2025· 1 citedOpen Access
not-yet-known not-yet-known not-yet-known unknown Fuelling Neuroblastoma: Genomic Analysis of Ketolytic and Glycolytic Gene Expression in Relation to MYCN Oncogene Amplification, Stage, and Prognosis
2025
Neurologists’ perspectives of cannabis-based medicines: results from an all-Ireland survey
Irish Journal of Medical Science (1971 -)·2025Open Access
The NLRP3 inflammasome: A central player in multiple sclerosis
Biochemical Pharmacology·2024· 4 cited
Cannflavin A inhibits TLR4-induced chemokine and cytokine expression in human macrophages
Natural Product Research·2024· 5 citedOpen Access
Toll-like receptor signalling as a cannabinoid target
Biochemical Pharmacology·2024· 15 citedOpen Access
Investigating cannabinoid modulation of endosomal toll-like receptor signalling
Planta Medica·2023
The effect of cannabinoid treatment on reactive human-induced pluripotent stem cell-derived astrocytes
Planta Medica·2023
Short Lecture "Anti-inflammatory potential of components of Cannabis sativa L. with relevance to multiple sclerosis pathogenesis"
Planta Medica·2023
Development of inflammasome assays to assess novel therapeutics in immune cells related to multiple sclerosis pathogenesis
Planta Medica·2023
Fueling Neuroblastoma: Genomic Analysis of Ketolytic and Glycolytic Gene Expression in Relation to MYCN Oncogene Amplification, Stage, and Prognosis
2023Open Access
Animated teaching improves student learning of human gastrulation and neurulation
Annals of Anatomy - Anatomischer Anzeiger·2023· 4 cited
Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis
Molecules·2022· 11 citedOpen Access
Role of Cannabinoids in Inflammation
Molecules·2022· 1 citedOpen Access
Cannabidiol modulation of oxidative stress and signalling
Neuronal Signaling·2021· 67 citedOpen Access
Phytocannabinoid‐dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity
British Journal of Pharmacology·2020· 22 citedOpen Access
MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ9-tetrahydrocannabinol and cannabidiol in human macrophages
Journal of Neuroimmunology·2020· 62 cited
Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids
European Journal of Neuroscience·2020· 23 citedOpen Access
Anti-inflammatory Potential of Terpenes Present in <i>Cannabis sativa</i> L.
ACS Chemical Neuroscience·2020· 42 cited
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Frequent Co-authors

Marina A. Lynch(9), Joseph P. McKenna(8), John F. Cryan(7), Veronica A. Campbell(7), André Toulouse(7), Anthony Lyons(6), John-Mark Fitzpatrick(6), Alison Barry(5), Ken D. O’Halloran(5), Mutahira Lone(5), Orna O’Toole(4), Christine McCreary(4), Tamara Vagg(4), Yvonne M. Nolan(3), Kingston H. G. Mills(3), Marie P. Fogarty(3), Melody Cui Sun(3), William Hind(3), Owen Cronin(3), Aisling Ryan(3)