Christopher B. Burge

IIT@MIT — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

79h-index71.7kcitations285works6.12yr avg
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Research Topics

RNA Research and Splicing(138), RNA and protein synthesis mechanisms(110), RNA modifications and cancer(108), MicroRNA in disease regulation(19), Cancer-related molecular mechanisms research(17)

Publications283 total

Widespread naturally variable human exons aid genetic interpretation
Nature Communications·2025Open Access
KATMAP infers splicing factor activity and regulatory targets from knockdown data
Nature Biotechnology·2025· 1 citedOpen Access
A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies
2025Open Access
A research roadmap for SCN8A-related disorders: addressing knowledge gaps and aligning research priorities across stakeholders
Orphanet Journal of Rare Diseases·2025· 4 citedOpen Access
Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease
Genome Medicine·2025· 4 citedOpen Access
LUC7 proteins define two major classes of 5′ splice sites in animals and plants
Nature Communications·2025· 8 citedOpen Access
Sequence-dependent and -independent effects of intron-mediated enhancement learned from thousands of random introns
Nucleic Acids Research·2025· 6 citedOpen Access
Sequence determinants of intron-mediated enhancement learned from thousands of random introns
2024· 4 citedOpen Access
Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro
Nature Communications·2024· 7 citedOpen Access
Widespread naturally variable human exons aid genetic interpretation
2024· 1 citedOpen Access
KATMAP: Inferring splicing factor activity and regulatory targets from knockdown data
2024· 3 citedOpen Access
Molecular and cellular context influences SCN8A variant function
JCI Insight·2024· 23 citedOpen Access
An interpretable model of pre-mRNA splicing for animal and plant genes
Science Advances·2024· 6 citedOpen Access
Understanding species-specific and conserved RNA-protein interactions <i>in vivo</i> and <i>in vitro</i>
2024Open Access
Regulatory features aid interpretation of 3′UTR variants
The American Journal of Human Genetics·2024· 13 citedOpen Access
Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
Genome biology·2024· 13 citedOpen Access
Quantifying negative selection in human 3ʹ UTRs uncovers constrained targets of RNA-binding proteins
Nature Communications·2024· 11 citedOpen Access
An Interpretable Model of pre-mRNA Splicing for Animal and Plant Genes
2023· 1 citedOpen Access
Molecular and Cellular Context Influences SCN8A Variant Function
2023· 6 citedOpen Access
Splicing quality control mediated by DHX15 and its G-patch activator SUGP1
Cell Reports·2023· 24 citedOpen Access
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Frequent Co-authors

David P. Bartel(9), G Yeo(9), Phillip A. Sharp(7), Eric T. Wang(6), Lee P. Lim(5), Rickard Sandberg(4), Brenton R. Graveley(4), Benjamin P. Lewis(3), Cassandra Bazile(3), Jiayu Chen(3), Neal Cody(3), Eric L. Van Nostrand(3), Rui Xiao(3), Nicole Lambert(3), Hairi Li(3), Xiang‐Dong Fu(3), Éric Lécuyer(3), Jessica A. Hurt(3), Kyle Kai‐How Farh(2), Shujun Luo(2)