Jan Scicinski

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index1.8kcitations71works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(16), Cancer, Hypoxia, and Metabolism(12), Analytical Chemistry and Chromatography(10), Innovative Microfluidic and Catalytic Techniques Innovation(7), Nitric Oxide and Endothelin Effects(5)

Publications71 total

Contributors
Elsevier eBooks·2019
Contributors
Elsevier eBooks·2017
Early Results: “ROCKET” a phase II Study of RRx-001, a novel triple epigenetic inhibitor, Resensitization to Irinotecan in Colorectal Cancer
Annals of Oncology·2015· 10 cited
The War on Cancer: A Military Perspective
Frontiers in Oncology·2015· 20 citedOpen Access
Targeting Hyponitroxia in Cancer Therapy
2015· 3 cited
Discovery and Development of RRx-001, a Novel Nitric Oxide and ROS Mediated Epigenetic Modulator
2015· 2 cited
Impact of hemoglobin nitrite to nitric oxide reductase on blood transfusion for resuscitation from hemorrhagic shock
Asian Journal of Transfusion Science·2015· 14 citedOpen Access
Abstract 906: Molecular imaging of RRx-001-induced oxidative stress in Nrf2-luciferase expressing SCC VII tumors in mice
Cancer Research·2014· 2 cited
Abstract 2068: RRx-001 oxidation of redox sensitive protein thiols in tumors measured by Gd-LC7-SH enhanced MRI In preclinical tumor models
Cancer Research·2014· 3 cited
Abstract 1420: RRx-001 inhibits glucose erythrocyte and tumor glucose 6-phosphate dehydrogenase
Cancer Research·2014· 5 cited
Rewriting the Epigenetic Code for Tumor Resensitization: A Review
Translational Oncology·2014· 38 citedOpen Access
Follow the ATP: Tumor Energy Production: A Perspective
Anti-Cancer Agents in Medicinal Chemistry·2014· 78 cited
The Capacity of Red Blood Cells to Reduce Nitrite Determines Nitric Oxide Generation under Hypoxic Conditions
PLoS ONE·2014· 31 citedOpen Access
Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment
Anti-Cancer Agents in Medicinal Chemistry·2014· 47 citedOpen Access
Novel nitric oxide generating compound glycidyl nitrate enhances the therapeutic efficacy of chemotherapy and radiotherapy
Biochemical and Biophysical Research Communications·2014· 38 cited
Development of Methods for The Bioanalysis of Rrx-001 and Metabolites
Bioanalysis·2014· 18 cited
The Implications of Hyponitroxia in Cancer
Translational Oncology·2014· 27 citedOpen Access
Two Case Reports of Resensitization to Previous Chemotherapy with the Novel Hypoxia-Activated Hypomethylating Anticancer Agent RRx-001 in Metastatic Colorectal Cancer Patients
Case Reports in Oncology·2014· 36 citedOpen Access
Abstract LB-86: Preliminary results from an ongoing phase I trial of RRx-001, a tumor selective cytotoxic agent.
Cancer Research·2013· 1 cited
Real Time Dynamic Imaging and Current Targeted Therapies in the War on Cancer: A New Paradigm
Theranostics·2013· 18 citedOpen Access
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Frequent Co-authors

Bryan Oronsky(17), Susan J. Knox(12), Miles Congreve(10), Steven V. Ley(10), Neil Oronsky(6), Gary R. Fanger(6), Bryan Oronsky(6), Corinne Kay(6), Stephen C. McKeown(5), Tony Reid(5), Shoucheng Ning(4), Michelle Lybeck(4), Nigel J. Parr(4), Peter Murray(4), Steve P. Watson(4), Robin A. E. Carr(4), Paul G. Wyatt(3), Mark D. Bednarski(3), Christopher Parker(3), Scott Caroen(3)